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4/5/1968 0:00

 Remover filtro <p>4/5/1968 0:00</p> Palavra-chave

Bone Morphogenetic Protein 3

 Remover Palavra-chave: <p>Bone Morphogenetic Protein 3</p>

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  • BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.

    Correspondências de palavras-chave:
    ... -Smad1, -5, and -8 (canonical BMP signaling), and also by phosphorylating MAPK such as Erk, Jnk, and p38 ...
    ... (BMP3 LacZ knock-in). To examine skeletal expression of BMP3, we analyzed heterozygous mice at 4 wk of ...
    ... Endocrinol, January 2012, 26(1):8794 FIG. 1. OBL and OCY express BMP3. Tibia from BMP3 4-wk-old LacZ knock-in ...
    ... ). As a first step, we confirmed that W20-17 cells express Acvr2b and nous Smad1/5/8 by Western blotting ...
    ... cells (Fig. 4A). We next confirmed that in increased p-Smad1/5/8 levels and robustly activated ...

    O Criador:

    Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S

    Descrição:

    Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...

    Tipo:

    Article

  • Comparative Genomics Identifies the Mouse BMP3 Promoter and an Upstream Evolutionary Conserved Region (ECR) in Mammals.

    Correspondências de palavras-chave:
    ... -eutherian animal (0/136). We also identified multiple conserved transcription factor binding sites in the ...
    ... ligands BMP2/4 and BMP5/6/7 (Dpp and Gbb in Drosophila, respectively) share dramatic identity, BMP3 is ...
    ... TGF-b/Activin and BMP ligands [9,10] and shares only 40% amino acid identity with the ancestral BMP2/4 ...
    ... ) supplemented with 10% FBS (Gibco). For RT-PCR analyses, cells were scraped into PBS, centrifuged for 5 min at ...
    ... BLASTN in sequential 500 nt sections from M. musculus against the full-length 5 kb region upstream of ...

    O Criador:

    LaVigne, AW, Kokabu, S, Lowery, Jonathan W., and Rosen, V.

    Descrição:

    The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...

    Tipo:

    Article