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1/1/2015

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Activin Receptors

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Faculty Publications and Research - MUCOM

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  • Allele-specific RNA Interference in FOP Silencing the FOP Gene

    Correspondências de palavras-chave:
    O Criador:

    Rosen, V. and Lowery, Jonathan W.

    Tipo:

    Article

  • BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.

    Correspondências de palavras-chave:
    ... induce ectopic bone formation through effects on skeletal progenitor cells present in adult animals (1 ...
    ... ; siRNA, small interfering RNA; TCA, trichloroacetic acid. Mol Endocrinol, January 2012, 26(1):8794 ...
    ... age and found that OBL and OCY are the source of BMP3 in adult bone (Fig. 1). These data are in ...
    ... with the idea that BMP3 is a product of mature OBL lineage cells (Fig. 1 and data not shown). Mol ...
    ... Endocrinol, January 2012, 26(1):8794 FIG. 1. OBL and OCY express BMP3. Tibia from BMP3 4-wk-old LacZ knock-in ...

    O Criador:

    Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S

    Descrição:

    Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...

    Tipo:

    Article

  • BMPR-II is Dispensable for Formation of the Limb Skeleton.

    Correspondências de palavras-chave:
    ... Limb Skeleton Laura W. Gamer,1* Kunikazu Tsuji,2 Karen Cox,1 Luciane P. Capelo,1 Jonathan Lowery,1 ...
    ... Hideyuki Beppu,3 and Vicki Rosen1 1 Department of Developmental Biology, Harvard School of Dental Medicine ...
    ... : 10.1002/dvg.20761 720 GAMER ET AL. FIG. 1. Loss of BMPR-II has no effect on early limb development. (a,b ...
    ... transcribed from 1 lg of total RNA from NB femurs with random primer using the Transcriptor First Strand cDNA ...
    ... dominant negative mutation in the alpha 1 (X) collagen gene produces spondylometaphyseal defects in mice ...

    O Criador:

    Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.

    Descrição:

    Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...

    Tipo:

    Article

  • Loss of BMPR2 Leads to High Bone Mass Due to Increased Osteoblast Activity

    Correspondências de palavras-chave:
    ... Science (2015) 128, 13081315 doi:10.1242/jcs.156737 density in the tibia by 9 weeks of age (Table 1; Fig ...
    ... 2015. Published by The Company of Biologists Ltd | Journal of Cell Science (2015) 128, 13081315 ...
    ... de Caestecker, 2010). The 1 Department of Biomedical Science, Marian University College of ...
    ... ) Received 19 May 2014; Accepted 2 February 2015 1308 canonical BMP pathway and activin and TGFb pathway ...
    ... type 1 alveolar program is promoted by SMAD2/3, but restricted by SMAD1/5/8 (Zhao et al., 2013), during ...

    O Criador:

    Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.

    Descrição:

    Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...

    Tipo:

    Article

  • N-linked Glycosylation of the Bone Morphogenetic Protein Receptor Type 2 (BMPR2) Enhances Ligand Binding

    Correspondências de palavras-chave:
    ... NIH Public Access Author Manuscript Cell Mol Life Sci. Author manuscript; available in PMC 2015 ...
    ... complex of type 1 and type 2 receptors to activate downstream transcription factors. It is well ...
    ... interacting with a hetero-oligomeric complex of type 1 and type 2 receptors to activate downstream ...
    ... across all animals [1], gene duplication events are * To whom correspondence should be addressed: Vicki ...
    ... example, the mammalian genome contains approximately twenty BMP ligands, seven type 1 receptors (ALK1/2/3 ...

    O Criador:

    Amich, J.M., Andonian, A., Rosen, V., and Lowery, Jonathan W.

    Descrição:

    The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...

    Tipo:

    Article