Strabismus “squint eyes” is a common disorder presenting in about 2% of children born each year. While there are several causes to this presentation, we demonstrated presentation caused by Peripheral nerve neuropathies,...
New imaging technologies and 3D rendering software, in addition to being useful diagnostic tools, allow us to augment patient education and further medical student and physician knowledge. 3D imaging modalities such as CT and...
Kidney transplantation is a major surgical intervention and patients undergoing counseling for this procedure do not always fully understand the essentials of this procedure. We present an improved way to facilitate patient...
A smartphone conveying gameplay movement instructions via encasement in a glowing football was designed to increase fitness and reduce obesity. While smartphone geolocation apps have flourished, people's ability to interact...
3D visualization software is a useful tool in
patient education because it allows patients to
put an image to what a physician is describing
to them. With an emphasis on education of
young athletes on the potential...
Context: The purpose of this project was to design a 3-dimensional method for visualizing structures within the brainstem with special attention to those involved in Lateral Medullary (Wallenberg) Syndrome. Wallenberg syndrome...
3D Visualization is a growing field in medicine. It is used for diagnosis, intervention design, and patient education. Medical students and physicians have little difficulty picturing a heart in their mind. Most physicians and...
The goal of this project is to build a teaching tool geared towards patients, students, and clinicians to further educate themselves about the anatomical and biochemical implications of various syndromes involving depression...
Context 3-Dimensional (3D) imaging is utilized in a variety of ways in medicine, including ultra-sound facial scanning in utero, breast cancer detection, and mapping blood vessels. 3D imaging can also be used to educate both...
Multiple sclerosis (MS), one of the most
prevalent immune-mediated neurological
disorders, is a chronic demyelinating disease
of the central nervous system that affects both
white and grey matter (Avasarala et....
3D visualization research is useful as a learning tool for medical students learning human anatomy and as a diagnostic tool for practicing physicians. Here we explore the use of this application of medical imaging in...
Background: Transposition of the Great Vessels (TGV) is a congenital heart defect (CHD) in which the great vessels are reversed – the aorta arises off of the right ventricle and the pulmonary trunks arises off the left...
We sought to evaluate a novel PPARδ inhibitor and explore whether this compound could synergize with known chemotherapeutic compounds to kill cancer cells in culture. Methods: A novel PPARδ inhibitor compound, Compound 9, was...
Unemployment is a substantial problem amongst veterans with mental illness. This pervasive vocational dysfunction results in poor financial, clinical, quality of life, and psychosocial outcomes. The Cognitive Behavioral Therapy...
Fibroblast growth factor-23 (FGF23) controls key responses to systemic phosphate increases through its phosphaturic actions on the kidney. In addition to stimulation by phosphate, FGF23 positively responds to iron deficiency...
The Activin and BMP signaling pathways exert reciprocal effects on myogenesis and skeletal muscle regeneration after injury. Signal transduction in both pathways is mediated by ligand- induced activation of transcriptional...
Over the past twenty years, opioid drug use has increased, causing an epidemic of opioid abuse that is killing tens of thousands of people every year. Current treatment options for opioid abuse disorder include alternative...
Objective: A proof-of-concept for a platform designed to provide simulations modeling, in three dimensions, anatomical pathology/dysfunctions(as defined by osteopathic diagnostic criteria). Design/Methods: Data from a two...
Antibiotic resistance has remained a topic of concern, and most current treatments prioritize preventing infections from antibiotic resistant pathogens. Hence, finding new antimicrobial compounds to suppress or rid of pathogens...
Diabetic ketoacidosis (DKA) is a life threatening complication of type 1 diabetes (T1D) resulting from ketone body production and metabolic acidosis occurring due to insulin deficiency, We sought to define the occurrence of DKA...
Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone formation...
Polyphenolic compounds (anthocyanins, flavonoid glycosides) in berries prevent the initiation, promotion, and progression of carcinogenesis in rat’s digestive tract and esophagus, in part, via anti-inflammatory pathways....
Book, presentation, and video are the current most popular modalities used
for grasping what is conceptual in OMM; Students entering medical school
have a higher degree of technological literacy. Education technology...
Sympathetic-like axon reflexes drive the initial increase in blood flow of the biphasic cutaneous vasodilation response of non-glabrous skin to local heating. It is currently unknown whether this process is involved in the...
The kidneys remove waste, produce hormones, and control blood pressure (BP). CKD is a disease spectrum, with stage one being least severe and stage five being the most severe often requiring dialysis.
In CKD, the kidneys...
Increased patient reliance on Internet-based health information has amplified the need for comprehensible online patient education articles. As suggested by the AMA and NIH, spine fusion articles should be between a 4th and 6th...
Introduction and Objective:
Accurate prediction of extraprostatic extension (EPE) can guide surgical treatment planning and maximize quality of life outcomes. We sought to analyze clinical and PSMA- PET CT EPE...
Segmental bone defects secondary lo high-energy trauma may not spontaneousfy heal and orthopedic surgeons call on the use of bone graft substitutes. Bone morphogenetic prntein-2 (BMP-2) and thrombopoietin (TPO) are an FDA...
Hypertension is an established risk factor for the development of atrial fibrillation (AF). We evaluated the association and population impact of hypertension defined using the new 2017 guidelines on risk of AF. In this...
Older adults (65+) are at an increased risk of contracting COVID-19 and have higher incidences of adverse events. Nursing home residents are particularly vulnerable due to congregate living and the need for personal care. CMS...
Introduction. Multiple myeloma (MM) is a hematological cancer characterized by the expansion and accumulation of monoclonal malignant plasma cells in the bone marrow (BM). Interactions between MM cells and cells of the bone/BM...
The goal of the IMPLICATION project is to provide a tool that will keep the already busy Physicians or Scientists up to date on the latest discoveries, in their respective specialties by providing a faster way to access the...
• Myroides spp. are non-motile, aerobic, gram-
negative bacilli that are traditionally
opportunistic pathogens1.
• P. stuartii is a urease-producing, gram-negative
bacillus2.
• Myroides infections have been reported
60...
Context: Though anatomy is a vital part of a medical student’s education, three-dimensional visualization often ends in the laboratory, months into a medical student’s journey to becoming a physician. Many physicians would...
A positive association between beta-carotene (BC)-rich food intake and a reduction in metabolic disorder incidence, including heart disease, is prevalent in humans. Similarly, preclinical research finds dietary BC...
It is estimated that more than 500,000 bone grafting surgeries occur yearly in the US to repair or replace defects caused by trauma, tumor resection, pathological degeneration and congenital malformations. Significant progress...
Menopause, an age-related loss of sex hormone production in women, is one of the most common causes of osteoporosis. Previous work has established that this loss of sex hormones, in particular estrogen, causes dramatic loss of...
Osteocyte (Ot)-derived Sclerostin (Scl) has local actions in bone mediated by Lrp 4/5/6 receptors, inhibiting bone formation and stimulating bone resorption by antagonizing Wnt signaling. Emerging evidence suggests that Scl...
Osteocyte (Ot)-derived Sclerostin (Scl), encoded by the SOST gene, regulates bone homeostasis by acting on osteoblasts, inhibiting bone formation and stimulating bone resorption. Emerging evidence suggest that Scl has...
Candida albicans and Gardnerella vaginalis are two common infectious organisms of the female urogenital tract. Single agent boric acid (BA) topical preparations have been a treatment for resistant gynecologic Candida and...
Persisters are a special group of quiescent and phenotypically unique cells in a given microbial population that survive antimicrobial insults or stresses but retain properties of the original population. Persisters have been...
Objectives: Arch branching has never been shown to influence recoarctation after extended end-to-end anastomosis via thoracotomy, yet in each study bovine arch identification is grossly underreported. This study aims to: 1)...
Brexanolone (ZULRESSO ™) is a novel approach to treat postpartum depression in adult women as a neuroactive steroid similar in chemical composition to the hormone allopregnanolone. It was approved for use in adult women...
Osteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer...
This project created the first website capable of searching published biomedical knowledge and returning a rank ordered list of actions most effective at improving health. These actions have font scaled based on the odds ratios...
Odds ratios are one of the methods in statistics to quantify how strongly the presence or absence of a property correlates with the presence or absence of another property in a given population. In the biomedical sciences they...
Burnout: A psychological syndrome from emotional exhaustion, depersonalization, and decreased personal accomplishment. Can also include cynicism (Stehman, et al., 2019).
Submitted as part of the BMS-515 Public Health and US...
Acute cardiac injury is a common cardiovascular complication of Covid19 and little is currently known about the long term implications of the complications and manifestations. Vascular complications show a hypercoagulable state...
The COVID-19 pandemic resulted in widespread mRNA vaccinations against SARS-CoV2. Side effects include fatigue, headache, myalgia,
fever, nausea, and lymphadenopathy, frequently experienced in younger recipients (16-55 years)...
Introduction: The Catholic medical ethic is supported by a rich intellectual tradition and remains foundational to the practice of medicine, especially within Catholic hospitals. In the US, the United States Conference of...
Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common cancers in the world, and even in developed countries like the United States, the five-year survival is only 65%. This already low survival rate drops...
The COVID-19 pandemic has created a unique situation for medical education worldwide as traditional medical training is not compatible with social distancing guidelines. Curriculums, content delivery, and procedures across...
Troglitazone (TRO), a peroxisome proliferator-activated receptor (PPAR) agonist, was a drug used as an anti-inflammatory and anti-diabetic agent. We had previously investigated a PPAR agonist that induced apoptosis in dose...
Hypoxia is a critical stress that can affect the normal development of a mammal embryo. Normally, Hypoxia is buffered by the Utero-placental apparatus in human infants; however, prematurely delivered infants may encounter...
Under the Hospital Readmission Reduction Program (HRRP), hospitals with high readmission rates are penalized by reductions in Medicare reimbursements. In particular, Parkview Noble hospital has experienced high readmission...
Gardnerella vaginalis (GV) is associated with bacterial vaginosis (BV), a dysbiosis that predisposes to preterm labor and increased susceptibility to sexually transmitted infections. The potential role of cytokines elaborated...
Background
Access to healthcare is a multidimensional concept influenced by many factors:
- Individuals of lower socioeconomic status tend to have a more difficult time accessing care leading to poorer health (McMaughan et...
Hiatal hernias are a very common medical condition and present as the pathologic passage of the foregut through the esophageal hiatus. While most hiatal
hernias are asymptomatic, presenting symptoms can easily progress to...
The low accessibility to mental health care in the United States is a major public health problem. This poster reviews the literature on the causes and consequences associated with low accessibility to mental health care, such...
In the study, we are analyzing the human genome in order to determine patterns that may tell something about how DNA functions. Patterns require an explanation: it is highly improbable that they are random occurrence. These...
Mobile Integrated Healthcare (MIH), also called Community Paramedicine (CP) or EMS 3.0, is a novel approach to prehospital care. With the use of specially trained paramedics, MIH-CP seeks to fill the current healthcare gaps in...
Background: Zone based photodynamic therapy (PDT) is a promising treatment option for actinic keratosis, superficial basal cell carcinoma, and in-situ squamous cell carcinoma. PDT has similar cure rates to 5-fluorouracil and...
Obstructive sleep apnea (OSA) is a prevalent sleep disorder that
typically arises when the muscles responsible for regulating the
upper airway excessively relax, ultimately causing narrowing or
constriction of the...
Increasing Demands for Mental Health Services
- Suicide is the 2nd leading cause of death in ages 10 -14 after
unintentional injury
- Pediatric mental health-related emergency department
visits have almost doubled in...
This project, OPTIMISTIC, is a retrospective study that focuses on Congestive Heart Failure(CHF) in Indiana Nursing homes. The purpose of the study was to find better ways in which to implement in house care to these CHF...
The Transforming Growth Factor-beta (TGFβ) superfamily is a large group of signaling molecules whose members play conserved roles in embryo specification, organogenesis, and tissue homeostasis. Structural considerations...
Coxiella burnetii is an obligate intracellular bacterium and causative agent of culture-negative endocarditis. Although Coxiella initially infects alveolar macrophages, it is found in lipid droplet (LD)-containing foamy...
Introduction: OPTIMISTIC is a project funded by the Centers for Medicaid and Medicare Services (CMS) that is aimed, in part, at the reduction of unnecessary hospitalization of nursing facility residents. Data from the initial...
What is Overmedication?
Overmedication is a very broad term with many definitions, each centering around the concept of administering too much medication(s). Though not to the point where it may be considered an overdose,...
Coxiella burnetii is a Gram-negative obligate intracellular pathogen, which spreads via inhalation. Although it initially infects alveolar macrophages, it can cause endocarditis several months to years after infection. This...
Coxiella burnetii is an obligate intracellular Gram-negative bacterium that causes Q fever in humans. While acute infection manifests as self-limiting flu-like illness, chronic Q fever presents as non-culturable endocarditis,...
Cryoglobulinemia is a condition where immunoglobulins precipitate at temperatures < 37°C causing damage to blood vessels of the skin, joints, peripheral nervous system, and kidneys. Diagnosis is difficult due to various...
INTRODUCTION: Cold limb immersion, a form of cryotherapy, can cause cardiovascu-lar changes due to cold-pain induced autonomic reflex. OBJECTIVE: This cryotherapy treatment side-effect has received less attention, and could...
Introduction: Externally added survival/growth factors are essential for the survival of healthy cells, however cancer cells are believed to be self-sufficient in supporting their auto-proliferation without the need of...
Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...
Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...
Background: A patent ductus arteriosus (PDA) is a common diagnosis among
extremely preterm infants. Unfortunately, this left to right shunt may result in
significant complications including pulmonary edema, pulmonary...
Postpartum preeclampsia refers to hypertension and proteinuria after delivery, and the occurrence of a seizure within six weeks after delivery is called postpartum eclampsia. Etiology is unknown but theorized to involve...
Students frequently report difficulty learning information presented at the end of long study sequences. Prior research has shown that information presented earlier in a study sequence interferes with learning of information...
Type 1 Diabetes is an autoimmune condition characterized by a deficiency in insulin due to the destruction of pancreatic β-cells. This leads to elevated blood glucose levels. The primary treatment involves daily administration...
Given disparities in medical and educational services, our study aimed to compare the current school supports in place and recommended supports for students with SCD (sickle cell disease) and CF (cystic fibrosis).
The design, administration, input, and evolution of an epigenetic database containing metadata across studies was created using cloud based tools with permission and blinding capacities. The database was designed to store the...
Bitter melon extract (BME) is known to inhibit breast cancer cells (MCF-7) proliferation. Due to the high metabolic rate of cancer cells, we hypothesized that low glucose levels are detrimental to cell survivability and that...
Bristles are mechanosensory organs in the Drosophila peripheral nervous system composed of four cells that adopt different fates and differentiate. These four cells (neuron, shaft, sheath, and socket) arise from a sensory organ...
30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous occlusion by proximal cuff inflation; CVAR with DPP), and ischemia (arterial occlusion by proximal cuff inflation) and sweat...
1.0°C. Arm and leg SkBF (laser-Doppler flowmetry) was decreased by engaging the venoarteriolar response (limb lowered ~30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous...
Context: Children with SMA suffer from scoliosis, global weakness, and Thoracic Insufficiency (TIS). Normalized pulmonary function tests are inadequate when evaluating these patients for improvement in PFTs. Objective: Forced...
Introduction: In 2012, approximately 19 million adults in the U.S. used some form of manipulative treatment as part of their overall healthcare. Suboccipital release (SOR) is a commonly used manual medicine technique of the...
Context: Skeletal muscle is essential for proper bodily functions by playing key roles in strength and movement, and it accounts for roughly 50% of our total body mass. Decreases in total muscle mass or mass-specific function...
Context: Skeletal muscle is essential for proper bodily functions by playing key roles in strength and movement, and it accounts for roughly 50% of our total body mass. Decreases in total muscle mass or mass-specific function...
1.5 million reported traumatic brain injuries (TBI) per year with varying degrees of severity that inflict injury at the cellular level. The Choroid Plexus (CP) plays a significant role in brain homeostasis. The CP has also...
Context: This research may provide insight into human articular cartilage development, repair mechanisms, and diseases such as arthritis. Objective: The purpose of this study is to compare the proximal femur articular cartilage...
30-60 min. Changes in SkBF spectral power in VLF and LF ranges from baseline to heating were determined using fast-Fourrier transform. Both groups increased spectral power within both the VLF and LF ranges. Compared to healthy...
• Traditional medical education typically consists of two years of didactic, lecture-based education {Years 1 and 2), as well as two years of clinical clerkships and patient interactions {Years 3 and 4)
• December 2019:...
Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Substantial evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone...
Osteoporosis is a disease that results from changes in bone mineral density (BMD). In the United States, over 10 million people have low BMD and have an increased risk for fractures, hospitalization and mortality. BMD is the...
Osteoporosis is a disease of decreased bone density that occurs when bone resorption exceeds bone formation, thereby placing individuals at greater risk of fracture and disability. We previously reported that deletion of the...