Arbor, Sage and Bondi, Joe

A smartphone conveying gameplay movement instructions via encasement in a glowing football was designed to increase fitness and reduce obesity. While smartphone geolocation apps have flourished, people's ability to interact...

Starcevich, Ashley and Dufeau, David

Context: The purpose of this project was to design a 3-dimensional method for visualizing structures within the brainstem with special attention to those involved in Lateral Medullary (Wallenberg) Syndrome. Wallenberg syndrome...

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LaFontaine, Michael, Metzler-Wilson, Kristen, and Willcox, Kendal

Over the past twenty years, opioid drug use has increased, causing an epidemic of opioid abuse that is killing tens of thousands of people every year. Current treatment options for opioid abuse disorder include alternative...

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Gebhardt, Garren, Stjepic, Sergej, Boget, Bradley, and Dufeau, David

Objective: A proof-of-concept for a platform designed to provide simulations modeling, in three dimensions, anatomical pathology/dysfunctions(as defined by osteopathic diagnostic criteria). Design/Methods: Data from a two...

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Arthur, Jon, Chlebek, Sylvia, Yates, Sydni, Jestes, Kelli, Newby, Jordan, Lowery, Jonathan, and Totten, Madeline

Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone formation...

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Ali, Mohammed, Alonso, Alvaro, and Rattani, Anas

Hypertension is an established risk factor for the development of atrial fibrillation (AF). We evaluated the association and population impact of hypertension defined using the new 2017 guidelines on risk of AF. In this...

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Nelson, Jessica, Evans-Molina, Carmella, Cregor, Meloney, Bellido, Teresita, Delgado-Calle, Jesus, Ferrari, Adam, and McAndrews, Kevin

Osteocyte (Ot)-derived Sclerostin (Scl), encoded by the SOST gene, regulates bone homeostasis by acting on osteoblasts, inhibiting bone formation and stimulating bone resorption. Emerging evidence suggest that Scl has...

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Cavanaugh, Nicholas, Rossi, Nicholas, Aldoss, Osamah, El-Hattab, Ahmed, Reinking, Ben, Turek, Joseph, and Conway, Brian

Objectives: Arch branching has never been shown to influence recoarctation after extended end-to-end anastomosis via thoracotomy, yet in each study bovine arch identification is grossly underreported. This study aims to: 1)...

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Donnelly, Stephen, Shadmand, Mehdi, Tobin, Kirby, Bender, Cecelia, Hum, Julia, Yates, Syndi, Jackson, Krista, Lowery, Jonathan, and Guan, Henry

Osteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer...

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Arbor, Sage, Given, Scott, Zhang, Eric, and Dryden, Ariel

Odds ratios are one of the methods in statistics to quantify how strongly the presence or absence of a property correlates with the presence or absence of another property in a given population. In the biomedical sciences they...

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Larsen, Bryan, Ogunbekun, Oladipupo, Schlehuser, Betsy, and Lowery, Jonathan

Gardnerella vaginalis (GV) is associated with bacterial vaginosis (BV), a dysbiosis that predisposes to preterm labor and increased susceptibility to sexually transmitted infections. The potential role of cytokines elaborated...

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Mulye, Minal, Silliman, Rachel, and Gilk, Stacey

Coxiella burnetii is an obligate intracellular bacterium and causative agent of culture-negative endocarditis. Although Coxiella initially infects alveolar macrophages, it is found in lipid droplet (LD)-containing foamy...

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Mulye, Minal and Leeds, Blake

Coxiella burnetii is a Gram-negative obligate intracellular pathogen, which spreads via inhalation. Although it initially infects alveolar macrophages, it can cause endocarditis several months to years after infection. This...

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Tobin, Kirby, Hum, Julia, Oberhelman, Forrest, and Waite, Timothy

Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...

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Graham, Robert, Miller, Patricia, Snyder, Brian, and Troy, Michael

Context: Children with SMA suffer from scoliosis, global weakness, and Thoracic Insufficiency (TIS). Normalized pulmonary function tests are inadequate when evaluating these patients for improvement in PFTs. Objective: Forced...

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Herber, Jake and Bertocci, Loren

Context: Skeletal muscle is essential for proper bodily functions by playing key roles in strength and movement, and it accounts for roughly 50% of our total body mass. Decreases in total muscle mass or mass-specific function...

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Morscher, Melanie, Steiner, Richard, Weiner, Dennis, Adamczyk, Mark, Childs, Robin, Yang, Julianne, Bundy, Joshua, and Landis, William

Context: This research may provide insight into human articular cartilage development, repair mechanisms, and diseases such as arthritis. Objective: The purpose of this study is to compare the proximal femur articular cartilage...

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Jestes, Kelli, Jackson, Krista, and Lowery, Jonathan

Osteoporosis is a disease of decreased bone density that occurs when bone resorption exceeds bone formation, thereby placing individuals at greater risk of fracture and disability. We previously reported that deletion of the...

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Tom, Cory and Gelfman, Daniel

Sudden cardiac death (SCD), is a relatively rare but dangerous occurrence for athletes across the globe. Increasing attention has been drawn to the condition, especially for the likes of highly competitive athletes. Current...

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Zahl, Sarah, Lowery, Jonathan, Messer, Kyle, and Cho, Tim

There are limited data regarding research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016 study of...

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