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2017-08-15 8:30
Remove constraint <p>2017-08-15 8:30</p> CreatorLowery, Jonathan W.
Remove constraint Creator: <p>Lowery, Jonathan W.</p>Search Results
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- ... Immunol Chapter 8: Unit 8 15 PubMed: 21104982203768442006953419016451. 37. Lodish HF (1988) Transport of ...... Smad1/5/8 and Id1 signaling axis, and that addition of chemical chaperones restores expression of the ...... Smad1/5/8 target Id1. These data indicate that the endogenous NMD negative BMPREx2 mutant product is ...... Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension. PLoS ONE 8(11): e80319. doi ...... proliferation, remodeling and vascular tone [8-14]. These diverse roles in regulating the pulmonary vasculature ...
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Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.
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More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...
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- ... 1,2 , Sarah Zahl 5,6 , Michael Baumann 7 and Jonathan W. Lowery 1,2,8, * 1 2 3 4 5 6 7 8 * Citation ...... April 2022 Accepted: 10 June 2022 Published: 15 June 2022 Publishers Note: MDPI stays neutral with ...... instruction in the basic scientific principles of research and support research involvement among students [8 ...... . Respondents ranked items using a Likert scale from 15 as follows: (1) definitely will not; (2) probably will ...... (65.5) 31.1% 13 (31.7) 23 (31.5) 15 (31.9) 17 (29.3) 20.1% 15 (26.8) 11 (13.1) 11 (19) 16 (21.6) 3.2 ...
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Zahl, Sarah, Hum, Julia M., Jackson, Krista L., Griffin, Nicole, Lowery, Jonathan W., Nick, Benjamin, Herber, Jake, Hamby, T., Baumann, Michael, and Ogunbekun, Oladipupo
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Involvement in research is regarded as a high-impact educational practice, which, for medical professionals, is associated with sharpened critical thinking and life-long learning skills, greater appreciation for evidence-based...
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BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.
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- ... or 0, 30, 60, or 90 ng empty vector along with 45 ng IdWT4F-luc reporter and 15 ng phRL-SV40 internal ...... % paraformaldehyde/PBS (pH 8), decalcified at 4 C in 0.5 M EDTA (pH 7.4) for 10 14 d, equilibrated in 15% sucrose for ...... (7, 8). Once activated, type I receptors propagate BMP signals by phosphorylating BMP-specific R ...... -Smad1, -5, and -8 (canonical BMP signaling), and also by phosphorylating MAPK such as Erk, Jnk, and p38 ...... by The Endocrine Society doi: 10.1210/me.2011-1168 Received June 30, 2011. Accepted October 17, 2011 ...
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Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S
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Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...
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- ... March 2011; Accepted 15 April 2011 Summary: Initiation of BMP signaling is dependent upon activation of ...... -IICKO E12 limb buds (n 5 3) using anti-pSmad1/5/8 antibody to evaluate BMP signaling and anti-p-Smad2/3 ...... collected limb buds from E12 embryos and analyzed them by western blot for alterations in p-Smad1/5/8 or p ...... -IICKO bones. (d,e) p-Smad1/5/8 immunohistochemistry of E16 humerus from control and BMPR-IICKO mice ...... not shown). Next, we performed immunohistochemistry for p-Smad1/5/8 on humeri from E16 BMPR-IICKO mice ...
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Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.
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Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...
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- ... Downloaded from http://cshperspectives.cshlp.org/ on April 10, 2017 - Published by Cold Spring ...... and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate ...... , and 8 are bona fide components of the canonical BMP signaling cascade. We use this narrow definition ...... of the TGF-b Family available at www.cshperspectives.org Copyright # 2017 Cold Spring Harbor ...... , 2017 - Published by Cold Spring Harbor Laboratory Press J.W. Lowery and V. Rosen Table 1. Components of ...
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Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-? family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate...
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- ... International Table 1: The proteins regulate adipogenesis and osteoblastogenesis. Number 1 2 3 4 5 6 7 8 9 10 11 ...... 12 13 14 15 16 17 18 19 20 21 22 23 Protein(s) Msx2 Dlk1/Pref-1 TAZ Wnt10b LIP Dec1 Hemooxygenase-1 ...... -binding family of proteins (C/EBPs) [8]. PPAR- is commonly referred to as the master regulator of ...... [15, 16]. RUNX2 controls osteoblast-related genes such as Osterix, collagen I, and osteocalcin [17 ...... osteoblast differentiation is required. Stem Cells International 8. Conclusion In this review we summarized ...
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Osteoblasts and bone marrow adipocytes originate from bone marrow mesenchymal stem cells (BMMSCs) and there appears to be a reciprocal relationship between adipogenesis and osteoblastogenesis. Alterations in the balance between...
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- ... Medicine (MU-COM) User on 05/03/2017 REVIEW 15. Zhang F, Qiu T, Wu X, et al. Sustained BMP signaling in ...... : jlowery@marian.edu Submitted August 31, 2015; revision received December 15, 2015; accepted January 21 ...... Osteopathic Medicine (MU-COM) User on 05/03/2017 REVIEW In this review, we identified studies with potential ...... . The RA-SMAD then sponse (activation of RA-SMADs 1, 5, and 8) is ances- complexes with the ...... . becoming increasingly common, especially in disease than 30 secreted ligands that signal through ...
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The transforming growth factor ? (TGF-?) superfamily is a large group of signaling molecules that participate in embryogenesis, organogenesis, and tissue homeostasis. These molecules are present in all animal genomes....
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- ... bone formation. International journal of biological sciences 8: 272288. 15. Daluiski A, Engstrand T ...... Region (ECR) in Mammals. PLoS ONE 8(2): e57840. doi:10.1371/journal.pone.0057840 Editor: Bernd Sokolowski ...... identified in deuterostomes, but are present as early as echinoderms (sea urchin [8]) and hemichordates ...... have high bone mass, indicating that BMP3 acts as a negative regulator of osteogenesis in vivo [15 ...... are conserved as early as sponges [2]. PLOS ONE | www.plosone.org 1 February 2013 | Volume 8 | Issue 2 ...
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The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...
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- ... . J Manipulative Physiol Ther, 2007. 30(8): p. 58492. 3. Standley, P.R. and K. Meltzer, In vitro ...... Run #3 CBA IL-6 20 15 15 100 pg/mL pg/mL pg/mL 10 10 50 5 5 +M ur y Run #3 CBA IL-8 150 2500 FR y In j ...... seeded on flexible collagen I-coated membranes and strained to mimic a repetitive motion strain in an 8 ...... represent the Injury strain. Cells that represent the Myofascial Release (MFR) strain underwent the same 8 ...... /IL-1F2, IL1ra/IL-1F3, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 p70, IL-13, IL-16, IL-17A, IL-17E ...
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This experiment analyzes three different techniques used in literature to detect cytokine release from cells in vitro: the Human Cytokine Array (HCA) by R&D Systems, the BD Cytometric Bead Array (CBA) assay, and protein...
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- ... . J Manipulative Physiol Ther, 2007. 30(8): p. 58492. 3. Standley, P.R. and K. Meltzer, In vitro ...... Run #3 CBA IL-6 20 15 15 100 pg/mL pg/mL pg/mL 10 10 50 5 5 +M ur y Run #3 CBA IL-8 150 2500 FR y In j ...... seeded on flexible collagen I-coated membranes and strained to mimic a repetitive motion strain in an 8 ...... represent the Injury strain. Cells that represent the Myofascial Release (MFR) strain underwent the same 8 ...... /IL-1F2, IL1ra/IL-1F3, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 p70, IL-13, IL-16, IL-17A, IL-17E ...
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This experiment analyzes three different techniques used in literature to detect cytokine release from cells in vitro: the Human Cytokine Array (HCA) by R&D Systems, the BD Cytometric Bead Array (CBA) assay, and protein...
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- ... Comparison of Geriatric and Nongeriatric Cohorts. Geriatr Orthop Surg Rehabil 2017; 8: 30-33 [PMID: 28255508 ...... BIOSIS Previews. The 2018 Edition of Journal Citation Reports cites the 2017 impact factor for WJSC as ...... ], clavicle[30], femoral neck[31], and floating knee injuries[32]. Delayed fracture healing, evidenced by a ...... We would like to thank Sue Samson for her administrative support. REFERENCES 1 2 3 4 5 6 7 8 9 10 11 ...... 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 WJSC https://www.wjgnet.com Hui SL, Slemenda CW ...
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Kacena, M.A., Karnik, S., Li, J., Promer, H.J., Clauss, M., Loghmani, M.T., Wagner, D.R., McKinley, T.O., Nielsen, J.J., Low, P.S., Lowery, Jonathan W., Gunderson, Z.J., and Fennimore, A.
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Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new...
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- ... morphogenetic proteins (BMPs), which activate SMADs 1, 5, and 8 and play an essential role in embryonic ...... for 30 min in 200 L total volume with gentle rocking. The loaded beads were then washed twice with PBS ...... serum restriction, select wells were Page 2 of 6 treated with 250 ng/mL 3F6 or control ascites for 30 ...... 10% DMEM containing 8 g/mL hexadimethrine bromide was added to each well and the plate was gently ...... SMAD1, 5, and 8 (Cell Signaling 9516 and 13820), anti-SMAD1 (Cell Signaling 6944), and anti--actin ...
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Hum, Julia M. , Totten, Madeline, Gorrell, Ruthann, Schoerning, Laura, Newby, Jordan B., Lowery, Jonathan W., Geyman, Logan J., and Lawless, Warren
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Originally appearing in BMC Research Notes as an open access article under the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)., The bone morphogenetic protein (BMP)...
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- ... morphogenetic proteins (BMPs), which activate SMADs 1, 5, and 8 and play an essential role in embryonic ...... for 30 min in 200 L total volume with gentle rocking. The loaded beads were then washed twice with PBS ...... serum restriction, select wells were Page 2 of 6 treated with 250 ng/mL 3F6 or control ascites for 30 ...... 10% DMEM containing 8 g/mL hexadimethrine bromide was added to each well and the plate was gently ...... SMAD1, 5, and 8 (Cell Signaling 9516 and 13820), anti-SMAD1 (Cell Signaling 6944), and anti--actin ...
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Newby, Jordan B., Hum, Julia M., Gorrell, Ruthann, Schoerning, Laura, Lowery, Jonathan W., Lawless, Warren, Totten, Madeline, and Geyman, Logan J.
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The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the transforming growth factor (TGF?) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal...
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- ... SMAD1/5/8; note that SMAD8 is also known as SMAD9) or SMAD2 and SMAD3 (hereafter denoted as SMAD2/3 ...... balance of SMAD1/5/8 and SMAD2/3 establishes an angiogenic switch between activation and resolution phases ...... type 1 alveolar program is promoted by SMAD2/3, but restricted by SMAD1/5/8 (Zhao et al., 2013), during ...... maintenance of epithelial cell polarity, where SMAD1/5/8 restricts the TGFbinduced epithelialmesenchymal ...... transition (Saitoh et al., 2013), and during regulation of skeletal muscle mass, where SMAD1/5/8 and SMAD2/3 ...
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Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.
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Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...
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- ... ; 71(16): 31653172. doi:10.1007/s00018-013-1541-8. N-linked glycosylation of the Bone Morphogenetic ...... canonical transcription factors (SMAD1/5/8) and a growing set of non-canonical effectors [8,5,9]. The ...... structure, localization, and function of glycoproteins [30] and each BMP type 2 receptor contains N ...... -receptors [49,50], and/or may be involved in proper intracellular trafficking [30]. Future studies will ...... (Invitrogen) via TA cloning using the primers detailed in Table S1 to generate the shuttle vector pJL69-8 ...
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Amich, J.M., Andonian, A., Rosen, V., and Lowery, Jonathan W.
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The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...
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- ... Wong Received: 14 February 2017; Accepted: 13 March 2017; Published: 15 March 2017 Abstract: The ...... Factor (Description) No. Transcription Factor (Description) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 ...... authors declare no conflicts of interest. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16 ...... channels which are expressed in gustatory tissues and in a variety of Molecules 2017, 22, 469; doi:10.3390 ...... /molecules22030469 www.mdpi.com/journal/molecules Molecules 2017, 22, 469 2 of 7 non-gustatory tissues such as the ...
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The special sense of taste guides and guards food intake and is essential for body maintenance. Salty and sour tastes are sensed via ion channels or gated ion channels while G protein-coupled receptors (GPCRs) of the taste...
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- ... [15]. This multiplex assay provided simultaneous Int. J. Mol. Sci. 2023, 24, 14392 8 of 9 measurement ...... . 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. Lucas, J.W.; Connor, E.M.; Bose, J. Back, Lower Limb ...... . Lowery 1,2,3,5,8,9, * 1 2 3 4 5 6 7 8 9 * Citation: Marciano, C.L.; Hiland, T.A.; Jackson, K.L.; Street ...... (LIX) which is the murine homologue of IL-8, CXCL-7, Granulocyte-Macrophage-Colony Simulating Factor ...... Factor (VEGF) at either 30 or 120 min post-treatment. Combined, our findings raise the possibility that ...
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Marciano, Carmela L., Hiland, Taylor A., Chu, TM, Kang, Kyung S., Lowery, Jonathan W., Jackson, Krista L., Street, Sierra, Maris, Carson, Ehrsam, Andrew, Hum, Julia M. , and Loghmani, M
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Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive...
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- ... @marian.edu. Hindawi Publishing Corporation Stem Cells International Volume 2016, Article ID 7290686, 15 ...... pathway activated by each ligand rather than name alone. The intracellular effectors SMAD1/5/8 actuate the ...... described by Urist [1, 2]. Proteins that participate in the activation of SMAD1/5/8, then, are bona fide ...... premature arrest of nephrogenesis [8]. Additionally, complete removal of BMP signaling sends inactive hair ...... schematized in Figure 1. Stem Cells International 2 1 3 BMP Cell surface Cytoplasm 2 1 4 5 SMAD1/5/8 9 8 6 ...
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Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-? family of ligands and are unequivocally involved in regulating stem cell behavior. Appropriate regulation of canonical BMP signaling is critical...
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