Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.

More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...

Article

Zahl, Sarah, Hum, Julia M., Jackson, Krista L., Griffin, Nicole, Lowery, Jonathan W., Nick, Benjamin, Herber, Jake, Hamby, T., Baumann, Michael, and Ogunbekun, Oladipupo

Involvement in research is regarded as a high-impact educational practice, which, for medical professionals, is associated with sharpened critical thinking and life-long learning skills, greater appreciation for evidence-based...

Article

Rosen, V. and Lowery, Jonathan W.

Article

Lowery, Jonathan W. and Rosen, V.

Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor-? family of ligands. BMPs exhibit widespread utility and pleiotropic, context-dependent effects, and the strength and...

Article

de Caestecker, M. and Lowery, Jonathan W.

Article

Lowery, Jonathan W. and de Caestecker, M.

Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...

Article

Anderson, L., de Caestecker, M.P, Jones, M., and Lowery, Jonathan W.

Conference

Jones, M.T., Frank, D.B., Mortlock, D.P., de Caestecker, M., Chandler, R.L., Anderson, L.A., and Lowery, Jonathan W.

The bone morphogenetic protein (BMP) type 2 receptor ligand, Bmp2, is upregulated in the peripheral pulmonary vasculature during hypoxia-induced pulmonary hypertension (PH). This contrasts with the expression of Bmp4, which is...

Article

Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S

Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...

Article

Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.

Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...

Article

Lowery, Jonathan W. and Rosen, V.

Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-? family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate...

Article

Rosen, Vicki and Lowery, Jonathan W.

Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-? family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate...

Article

Donnelly, Stephen OMS-4, Bender, Cecelia OMS-2, Jackson, Krista OMS-1, Guan, Henry OMS-4, Hum, Julia, Shadmand, Mehdi OMS-2, Tobin, Kirby OMS-2, Yates, Sydni OMS-2, and Lowery, Jonathan W.

Osteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer...

Article

Jimi, E., Kokabu, S, and Lowery, Jonathan W.

Osteoblasts and bone marrow adipocytes originate from bone marrow mesenchymal stem cells (BMMSCs) and there appears to be a reciprocal relationship between adipogenesis and osteoblastogenesis. Alterations in the balance between...

Article

Arthur JW, Hudnall, AM, and Lowery, Jonathan W.

The transforming growth factor ? (TGF-?) superfamily is a large group of signaling molecules that participate in embryogenesis, organogenesis, and tissue homeostasis. These molecules are present in all animal genomes....

Article

LaVigne, A.W., Kokabu, S., Rosen, V., and Lowery, Jonathan W.

Conference

LaVigne, AW, Kokabu, S, Lowery, Jonathan W., and Rosen, V.

The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...

Article

Kacena, M.A., Karnik, S., Li, J., Promer, H.J., Clauss, M., Loghmani, M.T., Wagner, D.R., McKinley, T.O., Nielsen, J.J., Low, P.S., Lowery, Jonathan W., Gunderson, Z.J., and Fennimore, A.

Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new...

Article

de Caestecker, M., Frump, A., and Lowery, Jonathan W.

Conference

Jimi, E., Kokabu, S, Sughiyama, G, Tsuchiya-Hirata, S, and Lowery, Jonathan W.

Article

Rosen V., Hudnall, J.B., Eaton, M.S., Newby, J.B., and Lowery, Jonathan W.

Conference

Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.

Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...

Article

Cox, K., Tsuji, K., Baron, R., Intini, G., Gamer, L., Lotinun S., Rosen, V., and Lowery, Jonathan W.

Conference

Dewar, B., Newby, J.B., Arthur, J., Lowery, Jonathan W., Wauson, E.M., Eaton, M.S., Foster, H., and Plattes, M.

Conference

Sato, T., Enoki, Y., Okubo, M., Kokabu, S, Yoda, T., Seta, Y, Toyono, T., Hitomi, S., Fukushima, Y., and Lowery, Jonathan W.

T1R3 is a T1R class of G protein-coupled receptors, composing subunit of the umami taste receptor when complexed with T1R1. T1R3 was originally discovered in gustatory tissue but is now known to be expressed in a wide variety...

Article

Zysik, Victoria S., Gries, Kevin, Jobe, Tyler K., Leeds, Benjamin P., Lowery, Jonathan W., and Griffin, Nicole

A significant amount of attention has been brought to the endocrine-like function of skeletal muscle on various tissues, particularly with bone. Several lines of investigation indicate that the physiology of both bone and...

Article

Amich, J.M., Andonian, A., Rosen, V., and Lowery, Jonathan W.

The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...

Article

Sato, T, Yoda, T, Kokabu, S, and Lowery, Jonathan W.

The special sense of taste guides and guards food intake and is essential for body maintenance. Salty and sour tastes are sensed via ion channels or gated ion channels while G protein-coupled receptors (GPCRs) of the taste...

Article

Cox, K., Gamer, L., Bosshardt, D., Rosen, V., Lowery, Jonathan W., and Chappuis, V.

Bone graft incorporation depends on the orchestrated activation of numerous growth factors and cytokines in both the host and the graft. Prominent in this signaling cascade is BMP2. Although BMP2 is dispensable for bone...

Article

Anderson, L., de Caestecker, M.P., Jones, M., and Lowery, Jonathan W.

Conference

Capelo, L.P., Chappuis, V., Kokabu, S, Lowery, Jonathan W., Rosen, V., Pazin, D., and Intini, G.

While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...

Article

Marciano, Carmela L., Hiland, Taylor A., Chu, TM, Kang, Kyung S., Lowery, Jonathan W., Jackson, Krista L., Street, Sierra, Maris, Carson, Ehrsam, Andrew, Hum, Julia M. , and Loghmani, M

Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive...

Article

Cox, K., Gamer, L.W., A, Rosen, V., Smith, E.A., and Lowery, Jonathan W.

Conference

Brookshire, B, Rosen, V., and Lowery, Jonathan W.

Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-? family of ligands and are unequivocally involved in regulating stem cell behavior. Appropriate regulation of canonical BMP signaling is critical...

Article