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1. Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

Correspondências de palavras-chave:: ... . Austin4, Mark de Caestecker1,5* 1 Department of Cell and Developmental Biology, Vanderbilt University ...

... Pulmonary Arterial Hypertension (PAH) only have a 50% 5year survival[1]. For this reason there was ...

... receptor complexes then activate the canonical SMAD 1/5/8 pathway, which in turn leads to the ...

... transcriptional regulation of target genes such as PLOS ONE | www.plosone.org 1 November 2013 | Volume 8 | Issue ...

... EDTA, 1% Triton X-100, 10% glycerol containing proteinase inhibitor cocktail and phosphatase inhibitor ...

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O Criador:: Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.
Descrição:: More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...
Tipo:: Article

2. Addressing Motivations and Barriers to Research Involvement during Medical School among Osteopathic Medical Students in the United States

Correspondências de palavras-chave:: ... 1,2 , Sarah Zahl 5,6 , Michael Baumann 7 and Jonathan W. Lowery 1,2,8, * 1 2 3 4 5 6 7 8 * Citation ...

... experiences intentionally designed with (1) a strong likelihood of gaining a publication, (2) financial ...

... ://doi.org/10.3390/educsci12060407 https://www.mdpi.com/journal/education Educ. Sci. 2022, 12, 407 2 of 12 1 ...

... . Respondents ranked items using a Likert scale from 15 as follows: (1) definitely will not; (2) probably will ...

... -COM (Table 1). Of the 272 students that responded, 56 (20.6%) were from the Class of 2022, 84 (30.9 ...

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O Criador:: Zahl, Sarah, Hum, Julia M., Jackson, Krista L., Griffin, Nicole, Lowery, Jonathan W., Nick, Benjamin, Herber, Jake, Hamby, T., Baumann, Michael, and Ogunbekun, Oladipupo
Descrição:: Involvement in research is regarded as a high-impact educational practice, which, for medical professionals, is associated with sharpened critical thinking and life-long learning skills, greater appreciation for evidence-based...
Tipo:: Article

3. Allele-specific RNA Interference in FOP Silencing the FOP Gene

Correspondências de palavras-chave:
O Criador:: Rosen, V. and Lowery, Jonathan W.
Tipo:: Article

4. The BMP Pathway and Its Inhibitors in the Skeleton

Correspondências de palavras-chave:
O Criador:: Lowery, Jonathan W. and Rosen, V.
Descrição:: Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor-? family of ligands. BMPs exhibit widespread utility and pleiotropic, context-dependent effects, and the strength and...
Tipo:: Article

5. BMP Signaling and Vascular Disease

Correspondências de palavras-chave:
O Criador:: de Caestecker, M. and Lowery, Jonathan W.
Tipo:: Article

6. BMP Signaling in Vascular Development and Disease.

Correspondências de palavras-chave:
O Criador:: Lowery, Jonathan W. and de Caestecker, M.
Descrição:: Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...
Tipo:: Article

7. Bmp2 and Bmp4 Exert Opposing Effects in Hypoxic Pulmonary Hypertension

Correspondências de palavras-chave:
O Criador:: Jones, M.T., Frank, D.B., Mortlock, D.P., de Caestecker, M., Chandler, R.L., Anderson, L.A., and Lowery, Jonathan W.
Descrição:: The bone morphogenetic protein (BMP) type 2 receptor ligand, Bmp2, is upregulated in the peripheral pulmonary vasculature during hypoxia-induced pulmonary hypertension (PH). This contrasts with the expression of Bmp4, which is...
Tipo:: Article

8. BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.

Correspondências de palavras-chave:: ... induce ectopic bone formation through effects on skeletal progenitor cells present in adult animals (1 ...

... ; siRNA, small interfering RNA; TCA, trichloroacetic acid. Mol Endocrinol, January 2012, 26(1):8794 ...

... age and found that OBL and OCY are the source of BMP3 in adult bone (Fig. 1). These data are in ...

... with the idea that BMP3 is a product of mature OBL lineage cells (Fig. 1 and data not shown). Mol ...

... Endocrinol, January 2012, 26(1):8794 FIG. 1. OBL and OCY express BMP3. Tibia from BMP3 4-wk-old LacZ knock-in ...

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O Criador:: Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S
Descrição:: Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...
Tipo:: Article

9. BMPR-II is Dispensable for Formation of the Limb Skeleton.

Correspondências de palavras-chave:: ... Limb Skeleton Laura W. Gamer,1* Kunikazu Tsuji,2 Karen Cox,1 Luciane P. Capelo,1 Jonathan Lowery,1 ...

... Hideyuki Beppu,3 and Vicki Rosen1 1 Department of Developmental Biology, Harvard School of Dental Medicine ...

... : 10.1002/dvg.20761 720 GAMER ET AL. FIG. 1. Loss of BMPR-II has no effect on early limb development. (a,b ...

... transcribed from 1 lg of total RNA from NB femurs with random primer using the Transcriptor First Strand cDNA ...

... dominant negative mutation in the alpha 1 (X) collagen gene produces spondylometaphyseal defects in mice ...

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O Criador:: Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.
Descrição:: Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...
Tipo:: Article

10. Bringing Attention to Lesser-known Bone Remodeling Pathways

Correspondências de palavras-chave:
O Criador:: Donnelly, Stephen OMS-4, Bender, Cecelia OMS-2, Jackson, Krista OMS-1, Guan, Henry OMS-4, Hum, Julia, Shadmand, Mehdi OMS-2, Tobin, Kirby OMS-2, Yates, Sydni OMS-2, and Lowery, Jonathan W.
Descrição:: Osteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer...
Tipo:: Article

1. Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

2. Addressing Motivations and Barriers to Research Involvement during Medical School among Osteopathic Medical Students in the United States

3. Allele-specific RNA Interference in FOP Silencing the FOP Gene

4. The BMP Pathway and Its Inhibitors in the Skeleton

5. BMP Signaling and Vascular Disease

6. BMP Signaling in Vascular Development and Disease.

7. Bmp2 and Bmp4 Exert Opposing Effects in Hypoxic Pulmonary Hypertension

8. BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.

9. BMPR-II is Dispensable for Formation of the Limb Skeleton.

10. Bringing Attention to Lesser-known Bone Remodeling Pathways

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1. Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

2. Addressing Motivations and Barriers to Research Involvement during Medical School among Osteopathic Medical Students in the United States

3. Allele-specific RNA Interference in FOP Silencing the FOP Gene

4. The BMP Pathway and Its Inhibitors in the Skeleton

5. BMP Signaling and Vascular Disease

6. BMP Signaling in Vascular Development and Disease.

7. Bmp2 and Bmp4 Exert Opposing Effects in Hypoxic Pulmonary Hypertension

8. BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.

9. BMPR-II is Dispensable for Formation of the Limb Skeleton.

10. Bringing Attention to Lesser-known Bone Remodeling Pathways

Filtre sua busca