Sarcopenia is a disease characterized by degeneration of muscle and strength that puts individuals at increased risk of functional impairment, physical disability, and mortality. The risk of disability is 1.5 to 4.6 times...
Hormone replacement therapy (HRT) is a common treatment for gender dysphoria, a condition where a person’s gender assigned at birth does not match their gender identify. For transgender men seeking to achieve virilization, HRT...
Kisspeptin together with its receptor, GPR54 (Kiss1R), are known for their function as the principal regulators of the onset of mammalian puberty. Given the characteristic growth spurt and bone development that occurs during...
Introduction: Kisspeptin together with its receptor, GPR54 (Kiss1 R), are known for their function as the principal regulators of the onset of mammalian puberty. Given the characteristic growth spurt and bone development that...
Objecti ve: Soft tissue manual therapies are commonly utilized by osteopathic physicians, chiropractors, physical therapists and massage therapists. These techniques are predicated on subjecting tissues to biophysical...
Osteoporosis is a disease of low bone mass that places individuals at enhanced risk for fracture, disability, and death. Hospitalizations for osteoporotic fractures exceeds those for heart attack, stroke, and breast cancer...
Mechanical loading is critical for bone remodeling. Voltage sensitive calcium channels (VSCCs) influence bone development and responses to loading. The α<sub>2</sub>δ<sub>1</sub> VSCC subunit regulates osteocyte...
Osteoporosis is a silent, dangerous pathology frequently undiagnosed until patients experience a major fracture. About 1 in 2 women and 1 in 4 men ages 50 and above will experience bone fractures due to osteoporosis. Fractures...
Context: Skeletal unloading due to disuse, disease, or aging increases bone loss and the risk of skeletal fracture. Conversely, mechanical loading is anabolic to the skeleton, promoting skeletal integrity through increased bone...