Donnelly, Stephen, Shadmand, Mehdi, Tobin, Kirby, Bender, Cecelia, Hum, Julia, Yates, Syndi, Jackson, Krista, Lowery, Jonathan, and Guan, Henry

Osteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer...

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Tobin, Kirby, Hum, Julia, Oberhelman, Forrest, and Waite, Timothy

Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...

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Gorrell, Ruthann, Yates, Sydni, Hudnall, Aaron, Hum, Julia, Geyman, Logan, Lawless, Warren, Totten, Madeline, Newby, Jordan, Lowery, Jonathan, and Schoerning, Laura

The Bone Morphogenetic Protein (BMP) signaling pathway comprises the largest subdivision of the Transforming Growth Factor (TGFβ) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal...

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Yi, Xin, Schneider, Artur, Wright, Christian, Hum, Julia, and Thompson, William

Context: Skeletal unloading due to disuse, disease, or aging increases bone loss and the risk of skeletal fracture. Conversely, mechanical loading is anabolic to the skeleton, promoting skeletal integrity through increased bone...

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Thompson, William R., Kelly, Madison, Bender, Cecelia, Hum, Julia, Oberhelman, Forrest, and Young, Collin

Voltage sensitive calcium channels (VSCCs) are key components in coordinating extracellular signaling that influence calcium (Ca2+) influx and subsequent downstream signaling in a variety of tissues including bone. Previous...

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