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DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.

Correspondências de palavras-chave:: ... 26 April 2012 Received in revised form 19 July 2012 Accepted 1 August 2012 Available online 23 ...

... of the head and neck (HNSCC) represent one of the ten most common cancers globally,1 and result in ...

... , Building 30, Room 211, Bethesda, MD 20892-4330, United States. Tel.: +1 301 496 6259; fax: +1 301 402 0823 ...

... protein standards or 4 ll tissue extract were diluted 1:6000 in RIPA buffer and added to the bioconjugates ...

... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...

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O Criador:: Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
Descrição:: OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
Tipo:: Article

Dual inhibition of vascular endothelial growth factor receptor and epidermal growth factor receptor is an effective chemopreventive strategy in the mouse 4-NQO model of oral carcinogenesis.

Correspondências de palavras-chave:: ... , comprehensive treatment plans must include improved chemopreventive strategies. Using the 4-nitroquinoline 1 ...

... the sixth most common malignancy in the world today (1). There will be over 35,000 new cases in the ...

... . First, OSCC is often diagnosed at an advanced stage. The 5-year Authors' Affiliations: Departments of 1 ...

... VEGF ligands are mediated through their binding to members of the VEGF receptor family (VEGFR-1, VEGFR ...

... were incubated using primary antibody to pVEGFR-2 1:300 (Abcam) or pEGFR 1:250 (Cell Signaling) for 1 ...

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O Criador:: Mankame, Tanmayi P., Zhou, Guolin, Wroblewski, Kristen, Lingen, Mark W., Doci, Colleen L., and Hasina, Rifat
Descrição:: Despite recent therapeutic advances, several factors, including field cancerization, have limited improvements in long-term survival for oral squamous cell carcinoma (OSCC). Therefore, comprehensive treatment plans must include...
Tipo:: Article

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

Correspondências de palavras-chave:: ... Factor (VEGF) and Sphingosine-1 Phosphate (S1P). In vivo, through constitutive and inducible endothelial ...

... family are Ras homolog gene family, member A (RhoA), Ras-related C3 botulinum toxin substrate 1 (Rac1 ...

... of a variety of cell surface 1 Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech ...

... : constantinos.mikelis@ttuhsc.edu) Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 1 ...

... factor (VEGF)10 and sphingosine-1-phosphate (S1P)11,12. Global deficiency of each Rho GTPase leads to ...

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O Criador:: Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
Descrição:: Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
Tipo:: Article

Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma

Correspondências de palavras-chave:: ... Research. 2939 Published OnlineFirst May 7, 2015; DOI: 10.1158/0008-5472.CAN-14-3121 Doci et al. Figure 1 ...

... , 2015. References 1. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144 ...

... Published OnlineFirst May 7, 2015; DOI: 10.1158/0008-5472.CAN-14-3121 Cancer Research Tumor and ...

... that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among the top 1% underexpressed genes in ...

... ); 293748. 2015 AACR. Introduction demonstrate intratumoral lymphangiogenesis that is associated with ...

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O Criador:: Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
Descrição:: Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
Tipo:: Article

Making Plastic Polymers from Milk

Correspondências de palavras-chave:: ... . It is easily done in the classroom and even at home! All you and your student will need is: 1 cup ...

... Disposable cups that hold at least 1 cup of milk Paper towels, cheesecloth, or gauze Plastic spoons ...

... seconds to 1 minute. Once you are done, take the curds out of the liquid and squeeze the excess liquid out ...

... 2020. Any questions, ideas, or suggestions, please email cdoci@marian.edu. Instructions 1. Read all ...

... table out and ready. 2. Obtain materials. _____2.1. Get 1 cup of hot milk and 4 teaspoons of your ...

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O Criador:: Roessler, Meghann E.H., Contreras, Alisson, Doci, Colleen L., and Tesfa, Martina
Descrição:: Presented at the 2020 Celebrate Science Indiana Festival. Celebrate Science Indiana, Indiana’s Premier Science Festival, is a public event that demonstrates the importance of studying science and the joy of discovery, the...
Tipo:: Presentation and Other

The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

Correspondências de palavras-chave:: ... thrombospondin-1 expression CL Doci, G Zhou and MW Lingen Thrombospondin-1 (TSP-1) is an endogenous inhibitor of ...

... angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 ...

... an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of TSP-1. Here ...

... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...

... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...

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O Criador:: Zhou, G., Doci, Colleen L., and Lingen, M.W.
Descrição:: Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
Tipo:: Article

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

Correspondências de palavras-chave:: ... The FASEB Journal Research Communication SDF-1/CXCL12 induces directional cell migration and ...

... . Molinolo,* and J. Silvio Gutkind*,1 *Oral and Pharyngeal Cancer Branch, National Institute of Dental and ...

... (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cellderived factor 1/C-X-C motif chemokine 12), to ...

... . Inhibition of mTOR complex 1 (mTORC1) by rapamycin [drug concentration causing 50% inhibition (IC50) = 5 nM ...

... ., Masedunskas, A., Weigert, R., Molinolo, A. A, Gutkind, J. S. SDF-1/CXCL12 induces directional cell migration ...

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O Criador:: Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
Descrição:: Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
Tipo:: Article

Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components.

Correspondências de palavras-chave:
O Criador:: Doci, Colleen L., Gutkind, J. Silvio, and Sakurai, Atsuko
Descrição:: Semaphorins are a family of membrane-bound and secreted type of proteins which were initially identified as chemorepulsive axon guidance molecules. Plexins and neuropilins are two major receptor families of semaphorins, and...
Tipo:: Article

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.

Dual inhibition of vascular endothelial growth factor receptor and epidermal growth factor receptor is an effective chemopreventive strategy in the mouse 4-NQO model of oral carcinogenesis.

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma

Making Plastic Polymers from Milk

The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components.

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