Ricerca
5/1/1959 0:00
Cancella il filtro <p>5/1/1959 0:00</p> CreatoreDoci, Colleen L.
Cancella il filtro Creatore: <p>Doci, Colleen L.</p>Risultati della ricerca
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- ... Minority barriers Senior Seminar Format Rankings 0 1 2 3 4 Group Discussion/ In-Class Activities 5 Markers ...... STEM Issues Global Issues Career Issues 0 2 4 6 8 10 12 IDENTITY AND INTERSECTIONALITY STEM Identity is ...
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Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...
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- ... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...... tissue (Fig. 2A). Tissues were scored 0, 1, or 2 based on staining intensity, with 0 being the lowest and ...... among women worldwide (1). CC development is strongly associated with human papillomavirus (HPV ...... TSP-1. Importantly, reintroduction of NOL7 suppressed tumor growth in vivo by 95% (32). These studies ...... Gynecol Pathol, Vol. 31, No. 1, January 2012 Cell Lines All cell lines were obtained from the ATCC ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... DSG3 (fg mL-1) 40 750 500 250 30 DSG3 PDDA HRP Ab2 I, nA 100 AuNPs 50 20 25 5 10 10 0 0 1 m ...... = 0.99315 30 I, nA 25 20 15 10 5 Voltage + H2O2 HQ amperometric signal 0 100 10 C 1000 [DSG3], pg mL-1 1000 ...... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... reproducibly detect DSG3 protein at levels down to 5 fg mL 1 in complex tissue extracts, with minimal non ...... 26 April 2012 Received in revised form 19 July 2012 Accepted 1 August 2012 Available online 23 ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... temperature, followed by two 5-min washes with PBS. Then the spheroids were blocked with 3% BSA in PBS for 1 h ...... Factor (VEGF) and Sphingosine-1 Phosphate (S1P). In vivo, through constitutive and inducible endothelial ...... family are Ras homolog gene family, member A (RhoA), Ras-related C3 botulinum toxin substrate 1 (Rac1 ...... of a variety of cell surface 1 Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech ...... : constantinos.mikelis@ttuhsc.edu) Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 1 ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... media supplemented with 5% FBS, 1 ng/ml TGF-1, or 10 ng/ ml TGF-1 was placed in the bottom well. The two ...... starved for 6 hours and then treated for 3 hours with either 0, 1, or 10 ng/ml TGF-1. Cells were fixed ...... transfected, reconstituted expression of Gq were allowed to migrate towards 0, 1, or 10 ng/ml TGF-1. C ...... minutes treatment with 0, 1, or 10 ng/ml TGF-1. D) G11/q-null and reconstituted cells co-expressing ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... . Membranes were blocked for 1 hour at room temperature in 5% milk in TBST and then probed with primary ...... that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among the top 1% underexpressed genes in ...... beyond 5 years (9, 10). This is partially attributed to the propensity of HNSCC to metastasize to ...... , we observed that SEMA3F is among the top 1% underexpressed genes (15). SEMA3F is a member of the ...... (1). Metastasis is the leading cause of morbidity in patients with a variety of solid tumors, where ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... , nasopharyngeal carcinoma and cervical cancer (CC) [1-19]. Using CC as a model for investigation, where LOH of ...... expression of the inhibitor of angiogenesis Thrombospondin-1 (TSP-1). One of the important features that ...... (Figure 1, first panel). Addition of cytosolic extract or ATP alone was also insufficient for transport ...... (Figure 1, second and third panels), suggesting that NOL7 localization is energy and complex dependent. At ...... 4C or in the presence of heat-inactivated cytosol, NOL7-GFP was restricted to the cytoplasm (Figure 1 ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... antitumorigenic cell phenotypes & 2013 Macmillan Publishers Limited Figure 5. NOL7 coimmunoprecipitates TSP-1 mRNA ...... . *Po3 10 5; **Po9 10 5; ***Po2 10 7. Figure 7. NOL7 post-transcriptionally stabilizes TSP-1 ...... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... in complete media containing 5 mg/ml a-amanitin for 0, 2, 4 or 6 hours. After treatment, RNA was ...... in 5% milk-TBST and probed overnight. Secondary was probed at 10 ng/ml for 1 h at room temperature ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... 5 0 shControl 1 0.0004 0.0003 0.0002 0.0001 0.0000 shControl J shControl shRictor shRictor 40 20 0 1 ...... 2 H 0.3 0.2 shRaptor 1 shRaptor 2 0.1 25 20 15 10 ** *** 5 0 0.0 shControl 1 2 shRaptor shRictor ...... . Inhibition of mTOR complex 1 (mTORC1) by rapamycin [drug concentration causing 50% inhibition (IC50) = 5 nM ...... cells 20 5 shCXCR4 0 28 Time (days) 50m 500m K shControl 21 H Normal LN 500m shControl shCXCR4 14 ...... Vehicle CXCL12 500m 3 I 7 *** 50 ventral tongue 60 Time (days) 0 100 80 0 10 150 100 0 1 shControl shCXCR4 ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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