Ricerca
3/6/1959 0:00
Cancella il filtro <p>3/6/1959 0:00</p> CreatoreDoci, Colleen L.
Cancella il filtro Creatore: <p>Doci, Colleen L.</p>Risultati della ricerca
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- ... STEM Issues Global Issues Career Issues 0 2 4 6 8 10 12 IDENTITY AND INTERSECTIONALITY STEM Identity is ...... Minority barriers Senior Seminar Format Rankings 0 1 2 3 4 Group Discussion/ In-Class Activities 5 Markers ...
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Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...
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- ... 13621627 13621698 0 0 3 UTR 30 UTR 30 UTR Predicted biologic consequence Loss of hsa-miR-1225-3p, -145 ...... detection. All sections were counterstained with hematoxylin and scored on a 0 to 2 scale, with 0 being the ...... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...... levels of endogenous normal NOL7. NOL7 protein expression was decreased by half in 6 of 13 (46%) cell ...... lines compared with 293 T control (Fig. 1A). We also found that 6 of 13 (46%) CC cell lines demonstrated ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... 100 m n=42 100 m n=6 0 SCC ADC SCLC Figure 2 Immunoreactivity of DSG3 in common tumor types. (A) Multi ...... resections. Here, we explored the feasibility of developing a sensitive assay system for desmoglein 3 (DSG3 ...... decades.3 HNSCC has a high propensity to metastasize to loco Corresponding author. Address: Oral and ...... mucosa and HNSCC lesions revealed a very high abundance of Desmoglein 3 (DSG3) in both non-neoplastic ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... gradually dissolved in M199 (6 g in 500 ml) under stirring at 4 C overnight. The supernatant from a 3 h ...... clarify the role of endothelial RhoA during tube formation, a 3-D sprouting assay was introduced, where ...... = 3). Full-length blots are presented in Supplementary Fig. 5. (D) Quantification of VEGF- (100 ng/ ml ...... ) and S1P-induced (500 nM) cell proliferation (n = 6) and cell migration (n = 6) (E) of HUVECs treated ...... ://doi.org/10.1038/s41598-019-48053-z 3 www.nature.com/scientificreports/ www.nature.com/scientificreports ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... starved for 6 hours and then treated for 3 hours with either 0, 1, or 10 ng/ml TGF-1. Cells were fixed ...... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... LifeActGFP were treated with 0, 1, or 10 ng/ml TGF-1 for 3 hours and assessed for cytoskeletal changes ...... Tech University Health Sciences Center, Amarillo, Texas, United States of America, 3 Department of ...... Pathology, University of California San Diego, La Jolla, California, United States of America, 6 Graduate ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... class 3 semaphorin family originally characterized in axonal guidance (16). In addition, semaphorins ...... participate in metastasis (3). Signicantly less is known about the role of lymphangiogenesis in cancer ...... microscope with images obtained every 30 seconds for a total of 3 hours, and analyzed using ZEN software ...... group were fed regular chow, while animals in the prevention group were fed 6 g doxycycline/kg chow 1 ...... disease onset every 3 days, and the observed lesions were assessed for length and width, and tumor volume ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... ://www.biomedcentral.com/1471-2121/11/74 Page 6 of 20 Figure 3 NOL7 contains three separate NLSs that are necessary for ...... organized as a single-stretch monopartite NLS: (K/R) 4-6 , or as a bipartite NLS in which there are two ...... small clusters typically separated by ten to twelve amino acids (K/R)2X10-12(KR)3. The SV40 large-T ...... ://www.biomedcentral.com/1471-2121/11/74 Page 3 of 20 Figure 1 NOL7 requires cytosolic factors for efficient nuclear ...... PK was evaluated. PS1, 2, 3 and 4 were cloned in frame with the C- terminus of the PK bearing an N ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... in complete media containing 5 mg/ml a-amanitin for 0, 2, 4 or 6 hours. After treatment, RNA was ...... monitored over a period of 30 (n 6 animals per group). Data are represented as means.e.m. Significance was ...... represented as means.e.m. Significance was calculated using Students t-test (n 6 animals per group). *Po2 ...... 10 6; ** Po1 10 10; n.s., not significant. Oncogene (2013) 4377 4386 & 2013 Macmillan ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... Vehicle CXCL12 500m 3 I 7 *** 50 ventral tongue 60 Time (days) 0 100 80 0 10 150 100 0 1 shControl shCXCR4 ...... Torin2treated HeLa cells. In each case, ANOVA was performed on 3 independent experiments. Data represent mean 6 ...... . After selection of cell pools resistant to puromycin, we 1061 0 10 0 10 1 10 2 10 3 Figure 3. Loss-of ...... . In each case, ANOVA was performed on 3 independent experiments. Data represent mean 6 SEM. *P , 0.05 ...... ] and mTORC1/ mTORC2 by Torin2 (IC50 = 6 nM), or by knocking down key mTORC1/2 components, Raptor and ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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