Ricerca
3/13/1959 0:00
Cancella il filtro <p>3/13/1959 0:00</p> CreatoreDoci, Colleen L.
Cancella il filtro Creatore: <p>Doci, Colleen L.</p>Risultati della ricerca
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- ... Minority barriers Senior Seminar Format Rankings 0 1 2 3 4 Group Discussion/ In-Class Activities 5 Markers ...... STEM Issues Global Issues Career Issues 0 2 4 6 8 10 12 IDENTITY AND INTERSECTIONALITY STEM Identity is ...
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Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...
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- ... 13621627 13621698 0 0 3 UTR 30 UTR 30 UTR Predicted biologic consequence Loss of hsa-miR-1225-3p, -145 ...... . NOL7 mRNA and protein levels were assessed in 13 CC cell lines and 23 consecutive CC specimens by real ...... detection. All sections were counterstained with hematoxylin and scored on a 0 to 2 scale, with 0 being the ...... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...... levels of endogenous normal NOL7. NOL7 protein expression was decreased by half in 6 of 13 (46%) cell ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... resections. Here, we explored the feasibility of developing a sensitive assay system for desmoglein 3 (DSG3 ...... decades.3 HNSCC has a high propensity to metastasize to loco Corresponding author. Address: Oral and ...... mucosa and HNSCC lesions revealed a very high abundance of Desmoglein 3 (DSG3) in both non-neoplastic ...... ), lymph node ( ) (n = 3), and lymph node (+) (n = 3). Results In a previous proteome-wide analysis of ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... prior to embryonic day 7.5 (E7.5)13, Rac1-knockout mice die prior to E9.5 due to germ-layer formation ...... the G12/13 GPCRs, leading to embryonic lethality during midgestation due to branching deficiencies of ...... clarify the role of endothelial RhoA during tube formation, a 3-D sprouting assay was introduced, where ...... = 3). Full-length blots are presented in Supplementary Fig. 5. (D) Quantification of VEGF- (100 ng/ ml ...... ://doi.org/10.1038/s41598-019-48053-z 3 www.nature.com/scientificreports/ www.nature.com/scientificreports ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... starved for 6 hours and then treated for 3 hours with either 0, 1, or 10 ng/ml TGF-1. Cells were fixed ...... LifeActGFP were treated with 0, 1, or 10 ng/ml TGF-1 for 3 hours and assessed for cytoskeletal changes ...... Tech University Health Sciences Center, Amarillo, Texas, United States of America, 3 Department of ...... ONE 12(3): e0173692. https://doi.org/10.1371/journal. pone.0173692 Editor: Paul McNeil, Augusta ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... class 3 semaphorin family originally characterized in axonal guidance (16). In addition, semaphorins ...... participate in metastasis (3). Signicantly less is known about the role of lymphangiogenesis in cancer ...... microscope with images obtained every 30 seconds for a total of 3 hours, and analyzed using ZEN software ...... disease onset every 3 days, and the observed lesions were assessed for length and width, and tumor volume ...... . 2A). Class 3 semaphorins function through a mechanism that involves negative regulation of integrin ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... small clusters typically separated by ten to twelve amino acids (K/R)2X10-12(KR)3. The SV40 large-T ...... ://www.biomedcentral.com/1471-2121/11/74 Page 3 of 20 Figure 1 NOL7 requires cytosolic factors for efficient nuclear ...... PK was evaluated. PS1, 2, 3 and 4 were cloned in frame with the C- terminus of the PK bearing an N ...... ://www.biomedcentral.com/1471-2121/11/74 Page 6 of 20 Figure 3 NOL7 contains three separate NLSs that are necessary for ...... -myc primary and Cy-3 conjugated secondary antibody. Costaining of the nucleus with DAPI is shown in ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... Oncogene (2013) 32, 43774386 & 2013 Macmillan Publishers Limited All rights reserved 0950-9232/13 ...... TSP-1 CL Doci et al 4380 Figure 3. NOL7 interacts with 30 end-processing proteins. (a) Lysate from ...... this was not an artifact of overexpression (Figure 4, lanes 3 and 4). This was not due to nonspecic ...... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... NOL7 specially interacts with the subunit CNOT3 (Figure 3). Similarly, NOL7 also interacts specically ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... Vehicle CXCL12 500m 3 I 7 *** 50 ventral tongue 60 Time (days) 0 100 80 0 10 150 100 0 1 shControl shCXCR4 ...... . After selection of cell pools resistant to puromycin, we 1061 0 10 0 10 1 10 2 10 3 Figure 3. Loss-of ...... (3). The C-XC motif chemokine receptor type 4 (CXCR4) 7-transmembrane G proteincoupled receptor binds ...... hematopoietic stem and progenitor cell mobilization. The PI3K/Akt/mTOR (phosphoinsoitide 3-kinase/ AKT ...... using m-Slides developed visible tumors after 3 wk, thus resembling the tongue model. Animals were ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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