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4/17/1959 0:00
Supprimer la restriction <p>4/17/1959 0:00</p> CréateurDoci, Colleen L.
Supprimer la restriction Créateur: <p>Doci, Colleen L.</p>Résultats de recherche
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- ... STEM Issues Global Issues Career Issues 0 2 4 6 8 10 12 IDENTITY AND INTERSECTIONALITY STEM Identity is ...... Minority barriers Senior Seminar Format Rankings 0 1 2 3 4 Group Discussion/ In-Class Activities 5 Markers ...
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Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...
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- ... -GTAGAGTATTTT TAGTGGGGTTTATT-30 and 50 -AAACTACACCA TAACCCA-30 ) (Figure 4). The PCR program used was 941C for ...... ) (Cell Signaling Technology, Danvers, MA). Results were quantied using 17 the Bio-Rad QuantityOne ...... detection. All sections were counterstained with hematoxylin and scored on a 0 to 2 scale, with 0 being the ...... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...... with 293T controls. Po2 104; Fig. 1B). Four of these cell lines, Ca Ski, ME-180, SiHa, and SW756 ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... protein standards or 4 ll tissue extract were diluted 1:6000 in RIPA buffer and added to the bioconjugates ...... lysates used for Western blot analysis and microuidic immunoarrays were made from primary tumors (n = 4 ...... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... 40 20 100 m OSCC Lung SCC Lung ADC Prostate Breast Prostate OSCC Rectum 0 100 m Colon 100 m 100 m ...... 100 m n=42 100 m n=6 0 SCC ADC SCLC Figure 2 Immunoreactivity of DSG3 in common tumor types. (A) Multi ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... toxin (20 ng/ml) treatment. Full-length blots are presented in Supplementary Fig. 4. (C) Representative ...... the VE-cadherin Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 4 ...... ). After 4-hydroxytamoxifen (4-OHT) administration during P2-P5 (Fig. 6B), as previously described36, we ...... repeated the analysis in P9 retinas, after 4-hydroxytamoxifen (4-OHT) administration during P2-P6.5 (Fig ...... / www.nature.com/scientificreports Figure 4. Endothelial RhoA-deficient embryos present no gross vascular ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... of America, 4 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial ...... in Gq and G11 leads oncogenic transformation [3, 4] and is particularly prevalent in the development ...... -mediated recombination system driven by the K14 promoter (K14-Cre, [17]), where Gna11-/-Gnaqf/f K14-Cre ...... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... . Then EdU (10 M) was incorporated for 4 h and cells were fixed in a 4% paraformaldehide/PBS solution ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... , although lymphatic invasion is one of the most relevant diagnostic parameters for solid tumors (2, 4, 5 ...... methods. Cell culture 293T-17, HaCat, COS-7, UMSCC2, and UMSCC17B cells were cultured in DMEM 10% FBS ...... determined using Pearson coefcient. SEMA3F purication Serum-free conditioned medium (CM) from 293T-17 cells ...... protein was separated by SDS-PAGE and transferred to polyvinylidene diuoride membrane overnight at 4 C ...... antibodies overnight at 4 C. Membranes were washed four times in Trisbuffered saline 1% Tween-20, probed ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... organized as a single-stretch monopartite NLS: (K/R) 4-6 , or as a bipartite NLS in which there are two ...... Biology 2010, 11:74 http://www.biomedcentral.com/1471-2121/11/74 Page 4 of 20 Figure 2 NOL7 is composed of ...... PK was evaluated. PS1, 2, 3 and 4 were cloned in frame with the C- terminus of the PK bearing an N ...... -WT PK PS1 C PS1 PS2 PS2 PS3 Np Np PS4 DAPI a-Myc Merge Figure 4 NOL7 contains three NLSs that are ...... compared to WT NOL7 and 2.6810 -5 and 1.2410-4 compared to the other double mutants N12(-) and N13 ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... in complete media containing 5 mg/ml a-amanitin for 0, 2, 4 or 6 hours. After treatment, RNA was ...... this was not an artifact of overexpression (Figure 4, lanes 3 and 4). This was not due to nonspecic ...... binding (Figure 4, lane 5). Finally, to demonstrate that this interaction was mRNA-specic and not a random ...... times the input RNA was performed. NOL7 binding was lost in the polyA treatments (Figure 4, lanes 6 and ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... 0 103 dorsal tongue Lymph nodes invaded (%) Cumulative population doubling 5 0 102 200 CXCR4 E 4 D ...... Health, Bethesda, Maryland Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 ...... Abbreviations: CXCL12, C-X-C motif chemokine 12; CXCR4, C-X-C motif chemokine receptor type 4; EGF, epidermal ...... (3). The C-XC motif chemokine receptor type 4 (CXCR4) 7-transmembrane G proteincoupled receptor binds ...... most of the sites that secrete its ligand, CXCL12, are frequently colonized by metastatic cells (4 ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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