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3/20/1959 0:00
Supprimer la restriction <p>3/20/1959 0:00</p> CréateurDoci, Colleen L.
Supprimer la restriction Créateur: <p>Doci, Colleen L.</p>Résultats de recherche
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- ... Minority barriers Senior Seminar Format Rankings 0 1 2 3 4 Group Discussion/ In-Class Activities 5 Markers ...... STEM Issues Global Issues Career Issues 0 2 4 6 8 10 12 IDENTITY AND INTERSECTIONALITY STEM Identity is ...
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Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...
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- ... 13621627 13621698 0 0 3 UTR 30 UTR 30 UTR Predicted biologic consequence Loss of hsa-miR-1225-3p, -145 ...... ://links.lww.com/IJGP/A6). Cycling conditions were 941C for 5 minutes, 35 cycles of 941C for 20 seconds, varied Tm ...... (CIN) I (n 22), CIN II (n 20), CIN III (n 23), and cervical squamous cell carcinoma (n 88 ...... detection. All sections were counterstained with hematoxylin and scored on a 0 to 2 scale, with 0 being the ...... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... 40 20 100 m OSCC Lung SCC Lung ADC Prostate Breast Prostate OSCC Rectum 0 100 m Colon 100 m 100 m ...... DSG3 (fg mL-1) 40 750 500 250 30 DSG3 PDDA HRP Ab2 I, nA 100 AuNPs 50 20 25 5 10 10 0 0 1 m ...... = 0.99315 30 I, nA 25 20 15 10 5 Voltage + H2O2 HQ amperometric signal 0 100 10 C 1000 [DSG3], pg mL-1 1000 ...... . Cancer Control 2009;16(3):2349. 20. Salhab M, Patani N, Mokbel K. Sentinel lymph node micrometastasis in ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... trafficking, regulation of gene expression and cell cycle progression1,3. The 20 known members of the Rho ...... clarify the role of endothelial RhoA during tube formation, a 3-D sprouting assay was introduced, where ...... toxin (20 ng/ml) treatment. Full-length blots are presented in Supplementary Fig. 4. (C) Representative ...... = 3). Full-length blots are presented in Supplementary Fig. 5. (D) Quantification of VEGF- (100 ng/ ml ...... ://doi.org/10.1038/s41598-019-48053-z 3 www.nature.com/scientificreports/ www.nature.com/scientificreports ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... starved for 6 hours and then treated for 3 hours with either 0, 1, or 10 ng/ml TGF-1. Cells were fixed ...... LifeActGFP were treated with 0, 1, or 10 ng/ml TGF-1 for 3 hours and assessed for cytoskeletal changes ...... Tech University Health Sciences Center, Amarillo, Texas, United States of America, 3 Department of ...... ONE 12(3): e0173692. https://doi.org/10.1371/journal. pone.0173692 Editor: Paul McNeil, Augusta ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... class 3 semaphorin family originally characterized in axonal guidance (16). In addition, semaphorins ...... participate in metastasis (3). Signicantly less is known about the role of lymphangiogenesis in cancer ...... antibodies overnight at 4 C. Membranes were washed four times in Trisbuffered saline 1% Tween-20, probed ...... microscope with images obtained every 30 seconds for a total of 3 hours, and analyzed using ZEN software ...... serum-free media with doxycycline for 20 hours. Cells were Cancer Research Downloaded from ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... ://www.biomedcentral.com/1471-2121/11/74 Page 3 of 20 Figure 1 NOL7 requires cytosolic factors for efficient nuclear ...... ://www.biomedcentral.com/1471-2121/11/74 Page 6 of 20 Figure 3 NOL7 contains three separate NLSs that are necessary for ...... loss in this neoplasm [20-25], we demonstrated that reintroduction of NOL7 suppresses in vivo tumor ...... passive diffusion through the NPC. However, proteins larger than ~20 kDa typically cross the NPC in a ...... small clusters typically separated by ten to twelve amino acids (K/R)2X10-12(KR)3. The SV40 large-T ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... TSP-1 CL Doci et al 4380 Figure 3. NOL7 interacts with 30 end-processing proteins. (a) Lysate from ...... this was not an artifact of overexpression (Figure 4, lanes 3 and 4). This was not due to nonspecic ...... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... NOL7 specially interacts with the subunit CNOT3 (Figure 3). Similarly, NOL7 also interacts specically ...... in complete media containing 5 mg/ml a-amanitin for 0, 2, 4 or 6 hours. After treatment, RNA was ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... cells 20 5 shCXCR4 0 28 Time (days) 50m 500m K shControl 21 H Normal LN 500m shControl shCXCR4 14 ...... Vehicle CXCL12 500m 3 I 7 *** 50 ventral tongue 60 Time (days) 0 100 80 0 10 150 100 0 1 shControl shCXCR4 ...... dissemination to locoregional lymph nodes could be LYVE 1 Tumor cells / LYVE 1 ** 100 80 60 40 20 0 shC shCXCR4 ...... . After selection of cell pools resistant to puromycin, we 1061 0 10 0 10 1 10 2 10 3 Figure 3. Loss-of ...... most of the animals (16 of 20) free of metastases at the end of the 1063 0 10 0 0 10 0 101 10 2 103 ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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