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2/13/1959 0:00
Supprimer la restriction <p>2/13/1959 0:00</p> CréateurDoci, Colleen L.
Supprimer la restriction Créateur: <p>Doci, Colleen L.</p>Résultats de recherche
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- ... STEM Issues Global Issues Career Issues 0 2 4 6 8 10 12 IDENTITY AND INTERSECTIONALITY STEM Identity is ...... Minority barriers Senior Seminar Format Rankings 0 1 2 3 4 Group Discussion/ In-Class Activities 5 Markers ...
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Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...
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- ... detection. All sections were counterstained with hematoxylin and scored on a 0 to 2 scale, with 0 being the ...... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...... tissue (Fig. 2A). Tissues were scored 0, 1, or 2 based on staining intensity, with 0 being the lowest and ...... intensity of staining ranging from 0 to 2 . 2-Hit hypothesis, loss of the rst allele of NOL7 by LOH must be ...... mutation in intron 5 was identied in 2 of the tumor samples and in 5 of the 13 cell lines examined ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... 100 m n=42 100 m n=6 0 SCC ADC SCLC Figure 2 Immunoreactivity of DSG3 in common tumor types. (A) Multi ...... more than 11,000 deaths each year in the US alone.2 The 5 year survival of newly diagnosed HNSCC ...... 2021. Elsevier Inc. All rights reserved. 94 V. Patel et al. / Oral Oncology 49 (2013) 93101 [18F]-2 ...... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... major cancer types Lung ADC Breast n: 42 47 16 45 37 13 298 100 + - Lung 100 m Colon % Cases 80 100 m 60 ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... Kubota 2, J. Silvio Gutkind7 & Constantinos M. Mikelis1 Imbalanced angiogenesis is a characteristic of ...... prior to embryonic day 7.5 (E7.5)13, Rac1-knockout mice die prior to E9.5 due to germ-layer formation ...... the G12/13 GPCRs, leading to embryonic lethality during midgestation due to branching deficiencies of ...... obvious in the 2-D sprouting assay (Fig. 2A,B). RhoA deficiency led to abrogation of VEGF-induced tube ...... /10.1038/s41598-019-48053-z 2 www.nature.com/scientificreports/ www.nature.com/scientificreports Figure 1 ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... , Indianapolis, Indiana, United States of America, 2 Department of Biomedical Sciences, School of Pharmacy, Texas ...... University Medical College of Georgia, UNITED STATES Received: August 13, 2016 Accepted: February 24, 2017 ...... % amino acid homology and are the main components of the Gq family of alpha proteins [2]. Gain of function ...... Rho-mediated formation of focal adherens junctions after histamine stimulation [13]. G11 and Gq have ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... . SEMA3F acts on its coreceptors, plexins and neuropilins, among which neuropilin-2 (NRP2) is highly ...... peritumoral vasculature is a critical diagnostic and prognostic biomarker (2). Angiogenesis is required for ...... , although lymphatic invasion is one of the most relevant diagnostic parameters for solid tumors (2, 4, 5 ...... , 2015; DOI: 10.1158/0008-5472.CAN-14-3121 Doci et al. neuropilin 2 (NRP2), and early studies indicated ...... cultured in EGM-2 (Lonza). All cells were cultured at 37 C in 5% CO2. UMSCC2 and UMSCC17B stable cell ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... nucleolar localization. Many ribosomal proteins show higher immobility and slower recovery Page 2 of 20 ...... and four putative NLSs within NOL7 (Figure 2). SAPS analysis revealed the existence of four highly ...... Biology 2010, 11:74 http://www.biomedcentral.com/1471-2121/11/74 Page 4 of 20 Figure 2 NOL7 is composed of ...... PK was evaluated. PS1, 2, 3 and 4 were cloned in frame with the C- terminus of the PK bearing an N ...... . The occupancy was described by the recovery half life (t1/2) and mobile fraction (Mf) of GFP-fusion ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... in complete media containing 5 mg/ml a-amanitin for 0, 2, 4 or 6 hours. After treatment, RNA was ...... Oncogene (2013) 32, 43774386 & 2013 Macmillan Publishers Limited All rights reserved 0950-9232/13 ...... . HuR regulates a number of angiogenesis-related transcripts, including VEGF, COX-2, and HIF-1a3538 and ...... and 2) or the cytoplasm (N123( ), clones 1 and 2). Cell nuclei were counterstained with DAPI and ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... . After selection of cell pools resistant to puromycin, we 1061 0 10 0 10 1 10 2 10 3 Figure 3. Loss-of ...... most of the animals (16 of 20) free of metastases at the end of the 1063 0 10 0 0 10 0 101 10 2 103 ...... 2 H 0.3 0.2 shRaptor 1 shRaptor 2 0.1 25 20 15 10 ** *** 5 0 0.0 shControl 1 2 shRaptor shRictor ...... CD31 K LYVE 1 L * 80 ** 60 shControl shControl 40 20 0 shControl 1 2 0.008 0.006 0.004 ** 0.002 0.000 ...... ] and mTORC1/ mTORC2 by Torin2 (IC50 = 6 nM), or by knocking down key mTORC1/2 components, Raptor and ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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