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10/30/1959 0:00
Supprimer la restriction <p>10/30/1959 0:00</p> CréateurDoci, Colleen L.
Supprimer la restriction Créateur: <p>Doci, Colleen L.</p>Résultats de recherche
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- ... STEM Issues Global Issues Career Issues 0 2 4 6 8 10 12 IDENTITY AND INTERSECTIONALITY STEM Identity is ...... Minority barriers Senior Seminar Format Rankings 0 1 2 3 4 Group Discussion/ In-Class Activities 5 Markers ...
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Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...
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- ... for 30 seconds, 721C for 2 minutes, and 721C for 10 minutes. PCR products were puried using the Wizard ...... 13621627 13621698 0 0 3 UTR 30 UTR 30 UTR Predicted biologic consequence Loss of hsa-miR-1225-3p, -145 ...... media were supplemented with 10% FBS, penicillin (100 mg/mL), and streptomycin. Media were as follows ...... primers region A (50 -GTGGTAGTAGGGTTG ATTGG-30 and 50 -AATAAACCCCACTAAAAAT ACTCTAC-30 ) and region B (50 ...... -GTAGAGTATTTT TAGTGGGGTTTATT-30 and 50 -AAACTACACCA TAACCCA-30 ) (Figure 4). The PCR program used was 941C for ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... DSG3 (fg mL-1) 40 750 500 250 30 DSG3 PDDA HRP Ab2 I, nA 100 AuNPs 50 20 25 5 10 10 0 0 1 m ...... = 0.99315 30 I, nA 25 20 15 10 5 Voltage + H2O2 HQ amperometric signal 0 100 10 C 1000 [DSG3], pg mL-1 1000 ...... streptavidin coated magnetic bead -10 0 400 800 1200 1600 t, s Ab2 -MB-HRP 40 35 y = -7.4659 + 14.987log(x) R ...... Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... factor (VEGF)10 and sphingosine-1-phosphate (S1P)11,12. Global deficiency of each Rho GTPase leads to ...... embryonic lethality by E9-10 due to deficiencies in lumen formation and failed blood circulation. Inducible ...... complete medium). Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 10 ...... was performed as described previously73. The cells were lysed on ice in RIPA buffer (10 mmol/L Tris ...... Inhibitor Cocktail; Thermo Scientific). Cell lysates were centrifuged at 13,000 rpm for 10 min at 4 C and ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... starved for 6 hours and then treated for 3 hours with either 0, 1, or 10 ng/ml TGF-1. Cells were fixed ...... transfected, reconstituted expression of Gq were allowed to migrate towards 0, 1, or 10 ng/ml TGF-1. C ...... minutes treatment with 0, 1, or 10 ng/ml TGF-1. D) G11/q-null and reconstituted cells co-expressing ...... LifeActGFP were treated with 0, 1, or 10 ng/ml TGF-1 for 3 hours and assessed for cytoskeletal changes ...... networks: emerging paradigms. Trends Pharmacol Sci. 2001; 22(7):36876. Epub 2001/06/30. PMID: 11431032 10 ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... beyond 5 years (9, 10). This is partially attributed to the propensity of HNSCC to metastasize to ...... of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bldg 30, Rm 320, Bethesda, MD 20892 ...... methods. Cell culture 293T-17, HaCat, COS-7, UMSCC2, and UMSCC17B cells were cultured in DMEM 10% FBS ...... microscope with images obtained every 30 seconds for a total of 3 hours, and analyzed using ZEN software ...... xenografts in SCID/NOD mice All animal studies were carried out according to NIHapproved protocols (ASP# 10 ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... carrier-mediated fashion [30]. This active nuclear transport of proteins is mediated by specific amino ...... . Putative Sequence (PS) 1, amino acids 1-10 appeared to be a monopartite NLS, while PS2, amino acids 88-112 ...... all four PSs [1-10, 88-257] was cytoplasmic (Figure 3B). Further, PS1 and PS2 were shown to function ...... individually as NLSs, as constructs missing PS2, PS3, and PS4 [88-257] or PS1, PS3, and PS4 [1-10, 113-257 ...... nucleoplasmic mutant N23(-), was least efficiently targeted. The single mutants demonstrated nearly 10% more ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...... recently has been shown to bind to the 30 UTR of TSP-1.39 While many of the well-characterized mRNA ...... , and others are critical for appropriate expression tied to transcriptional termination, 30 end ...... polyadenylated transcripts, specically with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 increases ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... Vehicle CXCL12 500m 3 I 7 *** 50 ventral tongue 60 Time (days) 0 100 80 0 10 150 100 0 1 shControl shCXCR4 ...... . After selection of cell pools resistant to puromycin, we 1061 0 10 0 10 1 10 2 10 3 Figure 3. Loss-of ...... most of the animals (16 of 20) free of metastases at the end of the 1063 0 10 0 0 10 0 101 10 2 103 ...... 2 H 0.3 0.2 shRaptor 1 shRaptor 2 0.1 25 20 15 10 ** *** 5 0 0.0 shControl 1 2 shRaptor shRictor ...... Institute of Dental and Craniofacial Research/National Institutes of Health, 30 Convent Dr., Building 30 ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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