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2017-08-15 8:30
Remove constraint <p>2017-08-15 8:30</p> CreatorDoci, Colleen L.
Remove constraint Creator: <p>Doci, Colleen L.</p>Search Results
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- ... /IlQrHD3i3D0OdRyi7TvSFl4Cf3VC1y0abggQZXdtwnfKZBYtws= on 03/08/2021 Colleen L. Doci, Ph.D., Tanmayi P. Mankame, M.S., Alexander Langerman, M.D., Kelly ...... the HTML and PDF versions of this article on the Journals Website, www.intjgynpathology.com. 15 DOI ...... -situ hybridization experiments using BAC clones and an 8-kb NOL7 genomic probe demonstrated consistent ...... primers region A (50 -GTGGTAGTAGGGTTG ATTGG-30 and 50 -AATAAACCCCACTAAAAAT ACTCTAC-30 ) and region B (50 ...... -GTAGAGTATTTT TAGTGGGGTTTATT-30 and 50 -AAACTACACCA TAACCCA-30 ) (Figure 4). The PCR program used was 941C for ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... = 0.99315 30 I, nA 25 20 15 10 5 Voltage + H2O2 HQ amperometric signal 0 100 10 C 1000 [DSG3], pg mL-1 1000 ...... Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive ...... , Building 30, Room 211, Bethesda, MD 20892-4330, United States. Tel.: +1 301 496 6259; fax: +1 301 402 0823 ...... ClinicalKey.com by Elsevier on March 08, 2021. For personal use only. No other uses without permission. Copyright ...... ClinicalKey.com by Elsevier on March 08, 2021. For personal use only. No other uses without permission. Copyright ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... chemopreventive agent. CBA mice were fed 4-NQO (100 g/mL) in their drinking water for 8 weeks and then randomized ...... -0135 Zhou et al. wound healing, reproduction, arthritis, and tumor formation (8). Because of its ...... phenotype. For example, the expression of either TGF- or EGFR results in increased expression of VEGF (15 ...... Methods Administration of 4-NQO and treatment with ZD6474 CBA mice, 6 to 8 weeks of age, were purchased ...... concentration of 100 g/mL. A fresh batch of water was prepared every week for each of the 8 weeks of ...
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Mankame, Tanmayi P., Zhou, Guolin, Wroblewski, Kristen, Lingen, Mark W., Doci, Colleen L., and Hasina, Rifat
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Despite recent therapeutic advances, several factors, including field cancerization, have limited improvements in long-term survival for oral squamous cell carcinoma (OSCC). Therefore, comprehensive treatment plans must include...
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- ... www.nature.com/scientificreports OPEN Received: 8 April 2019 Accepted: 27 July 2019 Published: xx ...... ) Quantification of number of nodes, number of junctions and total junction length (n = 8) (A) and representative ...... . 8). RhoA deficiency completely abrogated both S1P- and VEGF-induced cell migration (Fig. 8A) and ...... Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 8 www.nature.com ...... /scientificreports/ www.nature.com/scientificreports Figure 8. Effect of endothelial RhoA deficiency on VEGF- and S1P ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... sonicated for 3x10s on 30% power. Lysates were cleared by centrifugation at 10,000xg for 15 minutes at 4C ...... cytoskeleton at PLOS ONE | https://doi.org/10.1371/journal.pone.0173692 March 16, 2017 8 / 18 Epidermal loss ...... significant. (TIF) PLOS ONE | https://doi.org/10.1371/journal.pone.0173692 March 16, 2017 15 / 18 Epidermal ...... Technology Agency (JST), Kawaguchi, Saitama, Japan, 8 Department of Pharmacology, Max-Planck Institute for ...... al. (2017) Epidermal loss of Gq confers a migratory and differentiation defect in keratinocytes. PLoS ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... 15, 2015 Cancer Research Downloaded from cancerres.aacrjournals.org on March 8, 2021. 2015 American ...... , we observed that SEMA3F is among the top 1% underexpressed genes (15). SEMA3F is a member of the ...... of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bldg 30, Rm 320, Bethesda, MD 20892 ...... on March 8, 2021. 2015 American Association for Cancer Research. 2937 Published OnlineFirst May 7 ...... (14) July 15, 2015 perature in 5% milk, washed four times in TBST, and detected using chemiluminescent ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... carrier-mediated fashion [30]. This active nuclear transport of proteins is mediated by specific amino ...... ://www.biomedcentral.com/1471-2121/11/74 Page 8 of 20 Figure 5 Basic residues within each of the NLSs are required for ...... NLS2 and NLS3, with over a 15% decrease in efficiency for N23(-) compared to WT NOL7 and over 10 ...... calculated as the change in fluorescence intensity at 5, 6, 7, and 8 hours posttransfection (Figure 7B). Loss ...... 0.40, p = 6.1910-8). The most dramatic decrease was observed with the N23(-) mutant, which was imported ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 2008; 8: 880887. 15 Ferrara N, Davis ...... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...... recently has been shown to bind to the 30 UTR of TSP-1.39 While many of the well-characterized mRNA ...... , and others are critical for appropriate expression tied to transcriptional termination, 30 end ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... Institute of Dental and Craniofacial Research/National Institutes of Health, 30 Convent Dr., Building 30 ...... chemokines, such as IL-8, C-X-C motif chemokine (CXCL) 1, and CXCL2, are induced during inammatory events ...... Administration for hematopoietic stem and progenitor cell mobilization 0892-6638/15/0029-1056 FASEB for ...... signaling through CXCR4 has been shown to induce Akt phosphorylation/activation (14, 15). However, mTOR ...... manufacturers protocol. A total of 30 mg of protein was loaded in an SDS-PAGE, and proteins were transferred to ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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- ... : molecular switches at the midline. Trends Cell Biol npg Semaphorin signaling in angiogenesis 30 12 13 14 15 ...... Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Rm. 211, Bethesda, MD ...... blood vessel guidance during physiological and pathological blood vessel development [7, 8]. In this ...... directly through plexin-D1, independently of Nrps [15]. Plexins are single-pass transmembrane receptors and ...... and breast cancer cell lines [30], suggesting Sema3B exerts direct effects on cancer cells. In ...
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Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, and aberrant angiogenesis contributes to some of the most prevalent human diseases, including cancer....
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