Mikelis, C., Zheng, Y., Zahra, F., Gutkind, J., Zabet-Moghaddam, M., Akwii, R., Doci, Colleen L., Tullar, P., and Sajib, S.

Lymphangiogenesis is an essential physiological process but also a determining factor in vascular-related pathological conditions. Angiopoietin-2 (Ang2) plays an important role in lymphatic vascular development and function and...

Article

Ernstberger, Adrianna, Hall, Davyd, and Doci, Colleen L.

Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...

Poster

Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi

NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...

Article

Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.

OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...

Article

Mankame, Tanmayi P., Zhou, Guolin, Wroblewski, Kristen, Lingen, Mark W., Doci, Colleen L., and Hasina, Rifat

Despite recent therapeutic advances, several factors, including field cancerization, have limited improvements in long-term survival for oral squamous cell carcinoma (OSCC). Therefore, comprehensive treatment plans must include...

Article

Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace

Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...

Article

Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan

G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...

Article

Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.

Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...

Article

Zhou, Guolin, Lingen, Mark W., and Doci, Colleen L.

BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...

Article

Main, Kegan A., Mikelis, Constantinos M., and Doci, Colleen L.

Re-epithelialization after cutaneous injury is a complex and multifaceted process that incorporates numerous cellular components interacting in a myriad of pathways. One of the most crucial aspects of this process is the...

Article