McIntyre, Grace, Wong, Hoi Tong, Chan, Jason, Wright, Justin, and Lamendella, Regina

Objective

Many C. elegans aging studies use the compound 5-fluro-2ʹ-deoxyuridine (FUdR) to produce a synchronous population of worms. However, the effects of FUdR on the bacterial gene expression of OP50 E. coli, the primary...

Article

Wang, Lou, Staab, Trisha, Radeny, J, McIntyre, Grace, and Chan, Jason

The increase in our aging population in combination with the growing incidence of late-life conditions presents a need for research on healthy aging. Here, we present work examining the roles of sphingolipid metabolism on...

Conference Proceeding

Arvin, Chelsey L., Sibila, Zachary, Lamendella, R., Chan, Jason, and Staab, Trisha

Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in cgt...

Article

Staab, Trisha, McIntyre, Grace, Bromley, S., Raftery, D., Chan, Jason, Wang, L., Radeny, J., Bettcher, L., Guillen, Melissa, Peck, M. , and Kalil, A.

Lipid metabolism affects cell and physiological functions that mediate animal healthspan and lifespan. Lipidomics approaches in model organisms have allowed us to better understand changes in lipid composition related to age...

Research Paper