Chemotherapeutic agents, such as vincristine, are well known
antineoplastic and cytotoxic drugs, affecting patients broadly during
treatment of cancer. Well known side effects, such as constipation
and neuropathic pain,...
Children with acute lymphoblastic leukemia
(ALL) suffer a litany of therapy induced side
effects. Methotrexate is a common chemotherapy agent
administered for the treatment of ALL. Failure to clear methotrexate from the body...