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SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

Créateur:

Gutkind, J. Silvio, Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Molinolo, Alfredo A., Wang, Zhiyong, Patel, Vyomesh, Dorsam, Robert T., Martin, Daniel, Doci, Colleen L., Amornphimoltham, Panomwat, Mikelis, Constantinos M., Weigert, Roberto, Masedunskas, Andrius, and Dillenburg-Pilla, Patricia

La description:

Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...

Type:

Article