Cancer cells have shown to exhibit enhanced potential to metastasize via increased actin-myosin crossbridge formation, which requires increased Ca2+ influx via the voltage-gated calcium channels. This then leads to the...
Traditional medical education has recently seen major changes due to the coronavirus (COVID-19) pandemic. New pedagogical methods, including augmented reality (AR) and virtual reality (VR), are on the rise as alternatives to...
The unique conditions of microgravity and radiation exposure in space have a substantial impact on human tissue function, resulting in extreme bone loss. The goal of this project is to synthesize the current knowledge on bone...
•Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. •HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage...
Interprofessional education or IPE involves bringing individuals from two or more professions together to learn and communicate to improve future teamwork and collaboration. IPE research has shown that exposing future...
The DNA dependent protein kinase (DNA-PK) is a validated target for cancer therapeutics that drives the DNA damage response (DDR) and plays a critical role as a primary sensor in the non-homologous end joining (NHEJ) DNA double...
The United States spends well over $100 billion for millions of people affected by Alzheimer’s disease and related dementias (ADRD) and for their family caregivers. Most people with ADRD have multiple chronic comorbid...
Paraspinal inhibition is an osteopathic manipulative treatment (OMT) purported to work via the sympathetic nervous system and aid in restoring autonomic homeostasis. Despite clinical anecdotal evidence, the mechanism of action...
Introduction: Externally added survival/growth factors are essential for the survival of healthy cells, however cancer cells are believed to be self-sufficient in supporting their auto-proliferation without the need of...
Introduction: It is well documented in the literature that Bitter Melon Extract (BME) inhibits the growth and proliferation of MCF-7 breast cancer cells. While the exact mechanism of this inhibition is unknown, it is possible...
Osteocyte (Ot)-derived Sclerostin (Scl) has local actions in bone mediated by Lrp 4/5/6 receptors, inhibiting bone formation and stimulating bone resorption by antagonizing Wnt signaling. Emerging evidence suggests that Scl...
Context: Skeletal muscle is essential for proper bodily functions by playing key roles in strength and movement, and it accounts for roughly 50% of our total body mass. Decreases in total muscle mass or mass-specific function...
A historical analysis and comparison between rubella and zika reveals that neither virus became prominent until their respective congenital syndromes were classified. Rubella was first described in the 1750s but took until 1941...
Postpartum preeclampsia refers to hypertension and proteinuria after delivery, and the occurrence of a seizure within six weeks after delivery is called postpartum eclampsia. Etiology is unknown but theorized to involve...
Introduction: The Catholic medical ethic is supported by a rich intellectual tradition and remains foundational to the practice of medicine, especially within Catholic hospitals. In the US, the United States Conference of...
Sarcopenia is a disease characterized by degeneration of muscle and strength that puts individuals at increased risk of functional impairment, physical disability, and mortality. The risk of disability is 1.5 to 4.6 times...
Coxiella burnetii is an obligate intracellular Gram-negative bacterium that causes Q fever in humans. While acute infection manifests as self-limiting flu-like illness, chronic Q fever presents as non-culturable endocarditis,...
300 targets using very small quantities of protein. This revealed decreased activation of the mTOR pathway in tibiae of Nmu knock-out mice compared to controls, with reduced activity-associated phosphorylation of mTOR and the...
Peroxisome proliferator-activated receptors (PPARs) are important nuclear receptors in regulating macrophage lipid metabolism and modulating cellular inflammatory responses. In recent years, host cell PPARs have been linked to...
Osteoporosis is a silent, dangerous, pathology frequently undiagnosed until patients experience a major fracture. Fractures from osteoporosis lead to a 20% increase of mortality, revealing a need for novel anabolic therapies....
Introduction: OPTIMISTIC is a project funded by the Centers for Medicaid and Medicare Services (CMS) that is aimed, in part, at the reduction of unnecessary hospitalization of nursing facility residents. Data from the initial...
INTRODUCTION: Cold limb immersion, a form of cryotherapy, can cause cardiovascu-lar changes due to cold-pain induced autonomic reflex. OBJECTIVE: This cryotherapy treatment side-effect has received less attention, and could...
Candida albicans and Candida glabrata, are two clinically relevant strains of yeast. They make up a majority of commonly seen pathologies such as vaginal yeast infections, nosocomial infections, and infections of...
Coxiella burnetii is an obligate intracellular bacterium responsible for causing culture negative endocarditis. The manifestation of this condition several years following initial infection exhibits Coxiella’s ability to...
Introduction: The adenine diet is widely used in animal models to produce a tubu-lointerstitial fibrosis and inflammation that mimics human CKD in many aspects. These include the biochemical manifestations hyperphosphatemia and...
Vibrio cholerae is a Gram-negative bacterium that is the cause of the diarrheal disease cholera. Many strains have developed antibiotic resistance which allows these mutated strains to elude traditional treatment. Among the...
Troglitazone (TRO), a peroxisome proliferator-activated receptor (PPAR) agonist, was a drug used as an anti-inflammatory and anti-diabetic agent. We had previously investigated a PPAR agonist that induced apoptosis in dose...
Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common cancers in the world, and even in developed countries like the United States, the five-year survival is only 65%. This already low survival rate drops...
Context 3-Dimensional (3D) imaging is utilized in a variety of ways in medicine, including ultra-sound facial scanning in utero, breast cancer detection, and mapping blood vessels. 3D imaging can also be used to educate both...
A positive association between beta-carotene (BC)-rich food intake and a reduction in metabolic disorder incidence, including heart disease, is prevalent in humans. Similarly, preclinical research finds dietary BC...
The work of children is school; despite this, medical providers and educators often live completely separately in their child-family interactions from one another. Yet, medical issues impact school success and school issues are...
Phosphorus equilibrium in the body is regulated through uptake and release via the intestine, kidney and bone. These processes are coordinated through the activity and regulation of Fibroblast Growth Factor 23 (FGF23). FGF23 is...
70% at 2 weeks post-surgery (p>0.05). Stimulus- independent pain behavior was also evident in both vehicle and BMP-2 treated CSD animals as defined by asymmetric directed behaviors including flinching, licking, lifting, and...
Hyperglycemic clamps are used as a gold standard measurement of beta cell function, allowing for measurement of a biphasic insulin response. Under this technique, the plasma glucose concentration is raised to a target...
The goal of this project is to build a teaching tool geared towards patients, students, and clinicians to further educate themselves about the anatomical and biochemical implications of various syndromes involving depression...
Coxiella burnetii, the known causative agent of Q fever, is an obligate intracellular bacterium capable of infecting host alveolar macrophages and residing within these cells for several years. While causing mild symptoms at...
Mobile Integrated Healthcare (MIH), also called Community Paramedicine (CP) or EMS 3.0, is a novel approach to prehospital care. With the use of specially trained paramedics, MIH-CP seeks to fill the current healthcare gaps in...
Background: Inflammatory Bowel Disease (IBD) is a chronic relapsing and remitting inflammatory disease that affects the GI tract. IBD has two major types: Crohn’s disease and Ulcerative Colitis. IBD occurs when the immune...
Hormone replacement therapy (HRT) is a common treatment for gender dysphoria, a condition where a person’s gender assigned at birth does not match their gender identify. For transgender men seeking to achieve virilization, HRT...
Introduction: 23andMe provides consumers the opportunity to receive genetic information without involvement of a healthcare provider. As 23andMe continues to increase the number of variants and genetic diseases included in...
Coxiella burnetti is an obligate intracellular bacterial pathogen that spreads to humans via inhalation, infects alveolar macrophages and causes the worldwide zoonosis known as Q fever. Acutely, Coxiella infection manifests as...
This was a case study on a patient with SLE who received a heart transplant. Patients with SLE are generally not considered to be ideal candidates for transplantation due to auto-immunity involving many organ systems....