While utilization of Kidney Paired Donation (KPD) continues to increase, the potential is not fully realized. We surveyed kidney transplant (KTX) professionals to evaluate perceptions of barriers and solutions to increasing KPD...
Kisspeptin together with its receptor, GPR54 (Kiss1R), are known for their function as the principal regulators of the onset of mammalian puberty. Given the characteristic growth spurt and bone development that occurs during...
Introduction: Kisspeptin together with its receptor, GPR54 (Kiss1 R), are known for their function as the principal regulators of the onset of mammalian puberty. Given the characteristic growth spurt and bone development that...
Klotho is a regulatory anti-aging protein that is significantly expressed
in the choroid plexus, plays an important role in regulating the immune
response in the CNS, and diminishes with age. Klotho deficiency is...
Traditional medical education has recently seen major changes due to the coronavirus (COVID-19) pandemic. New pedagogical methods, including augmented reality (AR) and virtual reality (VR), are on the rise as alternatives to...
Traditional medical education has recently seen major changes due to the coronavirus (COVID-19) pandemic. New pedagogical methods, including augmented reality (AR} and virtual reality (VR), arc on the rise as alternatives to...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. Surrounded by a phospholipid monolayer, they store excess cellular free fatty acids and...
Osteoporosis is a disease of low bone mineral density (BMD) that affects 10 million Americans with an additional 34 million at risk for developing the disease. Current FDA-approved therapies for osteoporosis involve...
Osteoporosis is a disease of low bone mineral density that affects 10 million Americans and accounts for 1.5 million fractures annually. With an additional 34 million Americans at risk for developing the disease, osteoporosis...
Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
Objecti ve: Soft tissue manual therapies are commonly utilized by osteopathic physicians, chiropractors, physical therapists and massage therapists. These techniques are predicated on subjecting tissues to biophysical...
Osteoporosis is a disease of low bone mass that places individuals at enhanced risk for fracture, disability, and death. Hospitalizations for osteoporotic fractures exceeds those for heart attack, stroke, and breast cancer...
The unique conditions of microgravity and radiation exposure in space have a substantial impact on human tissue function, resulting in extreme bone loss. The goal of this project is to synthesize the current knowledge on bone...
The unique conditions of microgravity and radiation exposure in space have a substantial impact on human tissue function, resulting in extreme bone loss. The goal of this project is to synthesize the current knowledge on bone...
Context. Metabolic syndrome (MetS) refers to the combination of abdominal obesity, hyperglycemia or insulin resistance, dyslipidemia, and hypertension. MetS has been associated with morbidity and mortality after a variety of...
Mechanical loading is critical for bone remodeling. Voltage sensitive calcium channels (VSCCs) influence bone development and responses to loading. The α<sub>2</sub>δ<sub>1</sub> VSCC subunit regulates osteocyte...
Stomach dehiscence from the abdominal wall is a serious and potentially life-threatening complication of gastrostomy tube changes. A prospective series of 1136 gastrostomy tube changes in 415 different patients is examined to...
Introduction: According to the Centers for Disease Control and prevention (CDC), ensuring student access to needed physical and mental health care improves attendance, behavior, and achievement in the classroom. Academic...
Neurosurgical procedures result in surgically-induced brain injury (SBI) that causes postoperative complications including brain edema and neuronal apoptosis in the surrounding brain tissue. SBI leads to the release of...
Multiple drug resistance is becoming increasingly problematic in the U.S., where antibiotics are overused both in agriculture and healthcare. One way bacteria can develop this resistance is through acquisition of antibiotic...
Multiple osteochondromas (MO) is a rare genetic disorder characterized by accessory bone growths usually stemming from the epiphyseal plate oflong bones. MO affects about l in 50,000 lirn births. Complications of MO include...
What is it?
Organ transplantation is a surgical procedure in which a failing organ is replaced by a healthy organ .The healthy organ can come from a deceased or living donation
Who needs organ transplants?
Patients...
76% of the whole mouse genome. Of these, 840 genes met the t-test criteria, p<0.05. Canonical networks linked to EIF2 signaling, calcium ion signaling, and oxidative stress response were significantly enriched by the...
300 targets using very small quantities of protein. This revealed decreased activation of the mTOR pathway in tibiae of Nmu knock-out mice compared to controls, with reduced activity-associated phosphorylation of mTOR and the...
BACKGROUND: Non-Hodgkin Lymphoma (NHL) is a complicated disease that can result from a number of disease states in addition to typical cancerous processes. There are many treatment options for NHL. Typically, Rituximab, an...
Osteoporosis is a silent, dangerous pathology frequently undiagnosed until patients experience a major fracture. About 1 in 2 women and 1 in 4 men ages 50 and above will experience bone fractures due to osteoporosis. Fractures...
Spinal muscular atrophy (SMA) consists of a group of neuromuscular disorders characterized by degeneration of alpha motor neurons, leading to a lower motor neuron-type syndrome. Children afflicted with SMA 1 and 2 are prone to...
Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
Context: Skeletal unloading due to disuse, disease, or aging increases bone loss and the risk of skeletal fracture. Conversely, mechanical loading is anabolic to the skeleton, promoting skeletal integrity through increased bone...
Chemotherapeutic agents, such as vincristine, are well known
antineoplastic and cytotoxic drugs, affecting patients broadly during
treatment of cancer. Well known side effects, such as constipation
and neuropathic pain,...
Blunt cerebrovascular injury (BCVI) is rare but has been identified in trauma victims with increasing frequency in recent years due to improvements in imaging techniques and screening protocols. The incidence of BCVI is...
Due to the availability of information on the internet, patients are well informed of the several types of hernia repair available to them. They are also increasingly made aware of the litigious environment surrounding...
Purpose: To establish an ex vivo model of paclitaxel induced peripheral neuropathy that can be translated clinically using induced human neurons. Experimental Design: Human induced pluripotent stem cells (iPSCs) will be...
Papillary glioneuronal tumors (PGNTs) are rare, benign neoplasms that are typically solid or solid/cystic, well-circumscribed, parenchymal, solitary, and calcify. While intraventricular location, tumoral hemorrhage, and/or...
Rubella was first described in the 1750s but took until 1941 when Congenital Rubella Syndrome was characterized to become medically significant. Similarly, zika virus was discovered in 1947 but only made headlines in 2016 when...
A historical analysis and comparison between rubella and zika reveals that neither virus became prominent until their respective congenital syndromes were classified. Rubella was first described in the 1750s but took until 1941...
Eccrine sweating glands are divided into functional units: I) a bulbous secretory coil that generates precursor fluid, and 2) a reabsorptive duct that transports the fluid to the skin surface. The secretory coils reside in the...
The ability to communicate with patients effectively continues to be a major hindrance for physicians and physician offices. Coordinating care via conventional telecommunication, involving making calls to a healthcare facility...
Context: Patient reminder notifications have been widely utilized in the healthcare setting for several decades. Some clinics have even begun implementing “arrival time” notifications in lieu of the term “appointment time” in...
Interprofessional education or IPE involves bringing individuals from two or more professions together to learn and communicate to improve future teamwork and collaboration. IPE research has shown that exposing future...
The annual increase on price of pharmaceuticals are becoming a growing health concern in the United States for patients, prescribers, and policy makers.
Why is this an issue?
• Prices of newly marketed and pre-existing...
In the United States, one of the biggest issues that every state is experiencing is the shortage in doctors. Primary Care Physicians make up a huge percentage of the shortage in doctors. The Midwest took a huge hit by this...
Children with acute lymphoblastic leukemia
(ALL) suffer a litany of therapy induced side
effects. Methotrexate is a common chemotherapy agent
administered for the treatment of ALL. Failure to clear methotrexate from the body...
Background: It has been observed that patients with poor mental health are relatively frequent users of the Emergency Departments (ED). The objective of this study was to evaluate the prevalence of numerous behavioral health...
The United States spends well over $100 billion for millions of people affected by Alzheimer’s disease and related dementias (ADRD) and for their family caregivers. Most people with ADRD have multiple chronic comorbid...