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Lowery, Jonathan W.

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Familial Primary Pulmonary Hypertension

1. Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

Keyword matches:
Creator:: Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.
Description:: More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...
Type:: Article

2. BMP Signaling in Vascular Development and Disease.

Keyword matches:
Creator:: Lowery, Jonathan W. and de Caestecker, M.
Description:: Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...
Type:: Article

3. N-linked Glycosylation of the Bone Morphogenetic Protein Receptor Type 2 (BMPR2) Enhances Ligand Binding

Keyword matches:
Creator:: Amich, J.M., Andonian, A., Rosen, V., and Lowery, Jonathan W.
Description:: The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...
Type:: Article