Previous studies indicate that common fibular, tibial, and radial skin sympathetic nerve activity (SSNA) increases with physical stress in an exercise intensity-dependent manner but abates during ischemia when class Ill & IV...
The COVID-19 pandemic has created a unique situation for medical education worldwide as traditional medical training is not compatible with social distancing guidelines. Curriculums, content delivery, and procedures across...
Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage diagnoses...
Acute cardiac injury is a common cardiovascular complication of Covid19 and little is currently known about the long term implications of the complications and manifestations. Vascular complications show a hypercoagulable state...
Multi-system disorders may be difficult to differentiate between,
especially as genetic causes are still being defined and in light
of phenotypic variability. We present a case of a teen with
multiple congenital defects for...
Traditional medical education has recently seen major changes due to the coronavirus (COVID-19) pandemic. New pedagogical methods, including augmented reality (AR} and virtual reality (VR), arc on the rise as alternatives to...
The history and use of virtual and augmented reality dates back to the early 19th Century, Charles Wheatstone an English scientist, and inventor discovered that the brain interrupts stereoscopic photos and paintings differently...
Introduction: Kisspeptin together with its receptor, GPR54 (Kiss1 R), are known for their function as the principal regulators of the onset of mammalian puberty. Given the characteristic growth spurt and bone development that...
• Traditional medical education typically consists of two years of didactic, lecture-based education {Years 1 and 2), as well as two years of clinical clerkships and patient interactions {Years 3 and 4)
• December 2019:...
Eccrine sweating glands are divided into functional units: I) a bulbous secretory coil that generates precursor fluid, and 2) a reabsorptive duct that transports the fluid to the skin surface. The secretory coils reside in the...
Multiple osteochondromas (MO) is a rare genetic disorder characterized by accessory bone growths usually stemming from the epiphyseal plate oflong bones. MO affects about l in 50,000 lirn births. Complications of MO include...
Diabetic ketoacidosis (DKA) is a life threatening complication of type 1 diabetes (T1D) resulting from ketone body production and metabolic acidosis occurring due to insulin deficiency, We sought to define the occurrence of DKA...
The proposed solution is a self-reported, symptoms-based syndromic surveillance system that is universal, interactive, integrative, and combined with artificial intelligence. Once developed, this framework has the potential to...
, and yl, y2, and y3
• We continue to learn more about the involvement of PPARs in
immune modulation.
Conclusion
• Further understanding PPARs upstream pathways and interactions can contextualize pathophysiology in...
Brexanolone (ZULRESSO ™) is a novel approach to treat postpartum depression in adult women as a neuroactive steroid similar in chemical composition to the hormone allopregnanolone. It was approved for use in adult women...
Objecti ve: Soft tissue manual therapies are commonly utilized by osteopathic physicians, chiropractors, physical therapists and massage therapists. These techniques are predicated on subjecting tissues to biophysical...
Segmental bone defects secondary lo high-energy trauma may not spontaneousfy heal and orthopedic surgeons call on the use of bone graft substitutes. Bone morphogenetic prntein-2 (BMP-2) and thrombopoietin (TPO) are an FDA...
Book, presentation, and video are the current most popular modalities used
for grasping what is conceptual in OMM; Students entering medical school
have a higher degree of technological literacy. Education technology...
Raised just outside Cincinnati, in the rural community of Rossmoyne, Ohio, Aaron Belford Thompson, Priscilla Jane Thompson, and Clara Ann Thompson wrote poetry that addressed Black American life in the early twentieth century....
Obesity is accompanied by numerous systemic and tissue-specific derangements, including systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal muscle. Despite growing recognition that adipose...
Cutaneous wound healing is an intricate and multifaceted process. Despite these complexities, the distinct phases of wound healing provide a unique opportunity to evaluate the roles of different targets in these coordinated...
This chapter explores the ways in which the language educator can be successful teaching culture together with language specifically in an asynchronous online environment. It provides examples of content, activities and...
The theoretical paradigm of symbolic interaction has the potential to resonate with students because they can apply it to their everyday lives and to specific social exchanges. However, due to the abstract nature of theory,...
Introduction
The treatment of Cushing’s disease (CD) has been advanced well with the introduction of treatment options like transsphenoidal surgery, radiosurgery, bilateral adrenalectomy, and various classes of medication;...
Within the last quarter of the twentieth century and now well into the twenty-first, the historical novel has been a prolific and popular form in Spain for commentary on the dictatorship, the Transition and contemporary...
The authors present a stereotypical case presentation of X-linked hypophosphatemia (XLH) and provide a review of the pathophysiology and related pharmacology of this condition, primarily focusing on the FDA-approved medication...
Behavioural responses to communicative signals combine input from multiple sensory modalities and signal compensation theory predicts that evolutionary shifts in one sensory modality could impact the response to signals in...
Colorful ornaments are important visual signals for animal communication that can provide critical information about the quality of the signaler. In this study, we focused on different color characteristics of the abdominal...
The increase in our aging population in combination with the growing incidence of late-life conditions presents a need for research on healthy aging. Here, we present work examining the roles of sphingolipid metabolism on...
A Christian never gains all that Scripture offers by reading it with just one approach. Yet too often this is attempted--whether through an academic obsession with the historical-critical method or through a consumerist...
Women in medicine have made progress since Elizabeth Blackwell: the first women to receive her medical degree in the United States in 1849. Yet although women currently represent just over one-half of medical school applicants...
The article demonstrates a need and placement of Roman Catholic pastoral theology and serves to offer important revelations about the state of pastoral theology in the Catholic tradition. The overarching goal of this article is...
Donald Jackson, calligrapher to the Queen of England, envisioned of The St. John’s Bible in 1995; he found a patron in the monks at St. John’s University, Collegeville, Minnesota. While this manuscript is a product of the...
Today’s students come to college with widely varying academic skills, approaches to learning, and motivation levels. Many students have found it particularly difficult to learn remotely and have lost motivation. This session...
BACKGROUND AND LITERATURE REVIEW: Hand hygiene (HH) is the number one way to reduce healthcare associated infections (HAI). These infections account for increased morbidity and mortality and are linked with poor HH among...
Increased patient reliance on Internet-based health information has amplified the need for comprehensible online patient education articles. As suggested by the AMA and NIH, spine fusion articles should be between a 4th and 6th...
Community Health Needs Assessments and the developed strategies corresponding to any findings provide opportunities to improve the health of communities by targeted, coordinated efforts to meet the community needs. Thomas...
A smartphone conveying gameplay movement instructions via encasement in a glowing football was designed to increase fitness and reduce obesity. While smartphone geolocation apps have flourished, people's ability to interact...
The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a...
Context: Vibrio cholerae is the causative agent of cholera, the epidemic diarrheal disease. The colonization and subsequent diarrheal symptoms are produced due to toxin coregulated pilus (TCP) and cholerae toxin (CT)...
Context. Metabolic syndrome (MetS) refers to the combination of abdominal obesity, hyperglycemia or insulin resistance, dyslipidemia, and hypertension. MetS has been associated with morbidity and mortality after a variety of...
Students frequently report difficulty learning information presented at the end of long study sequences. Prior research has shown that information presented earlier in a study sequence interferes with learning of information...
Blunt cerebrovascular injury (BCVI) is rare but has been identified in trauma victims with increasing frequency in recent years due to improvements in imaging techniques and screening protocols. The incidence of BCVI is...
Introduction: According to the Centers for Disease Control and prevention (CDC), ensuring student access to needed physical and mental health care improves attendance, behavior, and achievement in the classroom. Academic...
In order to determine if loss of cell wall integrity contributes to boric acid toxicity towards wild type and drug resistant Candida organisms, yeast growth in osmoprotective-high-sorbitol medium was compared to growth...
Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteoclasts, and osteocytes. WNT signaling through low-density lipoprotein receptor related protein 5/6 (LRP5/LRP6) is one of the...
Context: Patients with large staghorn calculi are commonly treated with percutaneous nephrolithotomy (PCNL). PCNL access can be technically challenging and has potential to result in significant radiation exposure to both the...
Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
There are limited data regarding the level of research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016...
Osteoporosis is a disease of low bone mass resulting from bone resorption exceeding bone formation that places individuals at enhanced risk for fracture, disability, and death. There is an urgent and unmet need for novel...
30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous occlusion by proximal cuff inflation; CVAR with DPP), and ischemia (arterial occlusion by proximal cuff inflation) and sweat...
1.0°C. Arm and leg SkBF (laser-Doppler flowmetry) was decreased by engaging the venoarteriolar response (limb lowered ~30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous...
Context: Though anatomy is a vital part of a medical student’s education, three-dimensional visualization often ends in the laboratory, months into a medical student’s journey to becoming a physician. Many physicians would...
Osteoporosis, a disease of low bone mineral density, affects 10 million Americans and triggers significant health problems and considerable socioeconomic burdens. Current treatments for osteoporosis have significant...
Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Substantial evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone...
The Activin and BMP signaling pathways exert reciprocal effects on myogenesis and skeletal muscle regeneration after injury. Signal transduction in both pathways is mediated by ligand- induced activation of transcriptional...
Mechanical loading is critical for bone remodeling. Voltage sensitive calcium channels (VSCCs) influence bone development and responses to loading. The α<sub>2</sub>δ<sub>1</sub> VSCC subunit regulates osteocyte...
Insulin resistance is associated with a high cumulative risk of AD and reduced cerebral glucose metabolism. New data suggest that increased hexosamine biosynthesis pathway (HBP) activity induces insulin resistance in adipose...
Cryoglobulinemia is a condition where immunoglobulins precipitate at temperatures < 37°C causing damage to blood vessels of the skin, joints, peripheral nervous system, and kidneys. Diagnosis is difficult due to various...
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
3D Visualization is a growing field in medicine. It is used for diagnosis, intervention design, and patient education. Medical students and physicians have little difficulty picturing a heart in their mind. Most physicians and...
It is estimated that more than 500,000 bone grafting surgeries occur yearly in the US to repair or replace defects caused by trauma, tumor resection, pathological degeneration and congenital malformations. Significant progress...
Osteoporosis, a disease of low bone mineral density, affects 10 million Americans and is a significant health problem and a considerable socioeconomic burden. Current treatments for osteoporosis have significant limitations,...
Vibrio cholerae colonization of the host requires stringent response activation of TCP, the Toxin-Coregulated Pilus Cholera is an epidemic diarrheal disease caused by the Gramnegative bacterium Vibrio cholerae. In order to...
Palladium is often used in the synthesis of Active Pharmaceutical Ingredients (APIs), although it is toxic to ingest. As it is difficult to remove, it is imperative to develop optimal palladium sensors that can be utilized in...
Persisters are a special group of quiescent and phenotypically unique cells in a given microbial population that survive antimicrobial insults or stresses but retain properties of the original population. Persisters have been...
The goal of the IMPLICATION project is to provide a tool that will keep the already busy Physicians or Scientists up to date on the latest discoveries, in their respective specialties by providing a faster way to access the...
Multiple drug resistance is becoming increasingly problematic in the U.S., where antibiotics are overused both in agriculture and healthcare. One way bacteria can develop this resistance is through acquisition of antibiotic...
Purpose: The purpose of this study is to identify which texture analysis metrics calculated from apparent diffusion coefficient (ADC) maps from patients with head and neck squamous cell carcinomas (HNSCC) provide quantifiable...
Under the Hospital Readmission Reduction Program (HRRP), hospitals with high readmission rates are penalized by reductions in Medicare reimbursements. In particular, Parkview Noble hospital has experienced high readmission...
Bristles are mechanosensory organs in the Drosophila peripheral nervous system composed of four cells that adopt different fates and differentiate. These four cells (neuron, shaft, sheath, and socket) arise from a sensory organ...
Many Gram negative bacteria including Salmonella enterica species exhibit evolving multi-drug resistance coded for on their chromosome and on mobile genetic elements. Salmonella species carrying multi-drug resistance plasmids...
Clostridium difficile infection is particularly common in SOT patients and the consequences are severe. Fecal microbiota transplantation is an emerging, highly efficacious therapeutic modality for CDI but data on FMT success in...
We sought to evaluate a novel PPARδ inhibitor and explore whether this compound could synergize with known chemotherapeutic compounds to kill cancer cells in culture. Methods: A novel PPARδ inhibitor compound, Compound 9, was...
In conjunction with recent curricular changes at US medical schools, histology instruction has undergone significant changes. One major change has been the steady shift from traditional microscopy laboratory sessions to the...
Cold-induced vasodilation (CIVD) is a phenomenon involving a counterintuitive increase in skin blood flow during cold exposure. Although CIVD was first described in 1930, CIVD mechanisms remain unknown. CIVD research has...
Fibroblast growth factor-23 (FGF23) controls key responses to systemic phosphate increases through its phosphaturic actions on the kidney. In addition to stimulation by phosphate, FGF23 positively responds to iron deficiency...
Osteoporosis is a disease of low bone mineral density that affects 10 million Americans and accounts for 1.5 million fractures annually. With an additional 34 million Americans at risk for developing the disease, osteoporosis...
Unemployment is a substantial problem amongst veterans with mental illness. This pervasive vocational dysfunction results in poor financial, clinical, quality of life, and psychosocial outcomes. The Cognitive Behavioral Therapy...