Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...
INTRODUCTION: Two out of five U.S. citizens born after 2014 are expected to develop type 2 diabetes (T2D). T2D patients are at increased risk for fracture and impaired fracture healing, including: increased frequency of partial...
76% of the whole mouse genome. Of these, 840 genes met the t-test criteria, p<0.05. Canonical networks linked to EIF2 signaling, calcium ion signaling, and oxidative stress response were significantly enriched by the...
Voltage sensitive calcium channels (VSCCs) are key components in coordinating extracellular signaling that influence calcium (Ca2+) influx and subsequent downstream signaling in a variety of tissues including bone. Previous...
Introduction: In 2012, approximately 19 million adults in the U.S. used some form of manipulative treatment as part of their overall healthcare. Suboccipital release (SOR) is a commonly used manual medicine technique of the...
Coxiella burnetii is an obligate intracellular bacterial pathogen and a causative agent of culture-negative endocarditis. While Coxiella initially infects alveolar macrophages, it may disseminate and cause endocarditis up to 20...
Background: Recent studies indicated that chronic Salmonella infection contributes to increased risk of human colon cancer. In our previous studies, we found that Salmonella type III secretion effector protein AvrA can induce...
Objective Adolescent and young adult cancer survivors (AYACS: ages 15-39) have an 84.5% five -year survival rate. AYACS have a 10 times greater risk to develop cardiac disease compared to healthy peers. This is in part due to...
Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...
BACKGROUND: With an aging world population, there is an increased risk of fracture and impaired fracture healing. Enhancement of angiogenesis is one potential mechanism for improved fracture healing. The question then becomes:...
Introduction. Multiple myeloma (MM) is a hematological cancer characterized by the expansion and accumulation of monoclonal malignant plasma cells in the bone marrow (BM). Interactions between MM cells and cells of the bone/BM...
Kidney transplantation is a major surgical intervention and patients undergoing counseling for this procedure do not always fully understand the essentials of this procedure. We present an improved way to facilitate patient...
This project created the first website capable of searching published biomedical knowledge and returning a rank ordered list of actions most effective at improving health. These actions have font scaled based on the odds ratios...
Bradykinin, a local dermal kallikrein-kinin system product, increases skin blood flow via a cyclic GMP mechanism but is not the active cutaneous vasodilation molecule associated with cholinergic stimulation. However, the...
Introduction Delayed vasopressor initiation can occur with septic patients who arrive to the emergency department (ED) hemodynamically stable but decompensate later in their ED or hospital course. The relationship between...
Spinal muscular atrophy (SMA) consists of a group of neuromuscular disorders characterized by degeneration of alpha motor neurons, leading to a lower motor neuron-type syndrome. Children afflicted with SMA 1 and 2 are prone to...
There is a lack of data regarding real and perceived barriers to research participation among osteopathic medical students (OMS’s). We have previously addressed this open question by surveying incoming first-year OMS1’s and...
Background: It has been observed that patients with poor mental health are relatively frequent users of the Emergency Departments (ED). The objective of this study was to evaluate the prevalence of numerous behavioral health...
There are limited data regarding the research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016 study of...