Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-? family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate...
INTRODUCTION: Stomach dehiscence from the abdominal wall is a serious and potentially life-threatening complication of gastrostomy tube changes. This retrospective study evaluates gastric aspiration as an inexpensive and safe...
Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...
<strong>Targeting early steps in amyloid-beta production:</strong> Alzheimer's disease (AD) has a long history as the “amyloid deposit” disorder. Many disorders are now known to be caused by protein ?-sheet misfolding and...
Amyloid beta (A?), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic A? fibers historically seen postmortem. While Alzheimer targets, such as...
Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC)...
Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC)...
Case Study:
Short Limbs, Earlier Diagnosis: Antenatal Presentation of Cornelia de Lange Syndrome.
30-year old female presented at 35 weeks gestation to Maternal-Fetal Medicine with intrauterine growth restriction (IUGR) •...
Hypersensitivity pneumonitis is a unique form of interstitial lung disease that is diverse in its presentation and etiology. • Hypersensitivity pneumonitis is mediated by an inflammatory reaction to inhalation of an...
BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common "gold standard" resource used building curricula are medical objectives suggested by national...