INTRODUCTION: Two out of five U.S. citizens born after 2014 are expected to develop type 2 diabetes (T2D). T2D patients are at increased risk for fracture and impaired fracture healing, including: increased frequency of partial...
76% of the whole mouse genome. Of these, 840 genes met the t-test criteria, p<0.05. Canonical networks linked to EIF2 signaling, calcium ion signaling, and oxidative stress response were significantly enriched by the...
Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...
Gardnerella vaginalis (GV) is associated with bacterial vaginosis (BV), a dysbiosis that predisposes to preterm labor and increased susceptibility to sexually transmitted infections. The potential role of cytokines elaborated...
Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super...
Introduction: Bitter melon extract (BME) is known to inhibit breast cancer cells (MCF-7) proliferation. The PKC and ROK play critical roles in cell division, migration, and survival. However, the roles of protein kinase-c (PKC)...
Objectives: Arch branching has never been shown to influence recoarctation after extended end-to-end anastomosis via thoracotomy, yet in each study bovine arch identification is grossly underreported. This study aims to: 1)...
The Bone Morphogenetic Protein (BMP) signaling pathway comprises the largest subdivision of the Transforming Growth Factor (TGFβ) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal...
BACKGROUND: Non-Hodgkin Lymphoma (NHL) is a complicated disease that can result from a number of disease states in addition to typical cancerous processes. There are many treatment options for NHL. Typically, Rituximab, an...
The spread of antibiotic resistance among bacteria is a potential threat to the effectiveness of antibiotics currently used for controlling common human pathogens. Also, the resistance to current antibiotics is spreading at a...
Over the past twenty years, opioid drug use has increased, causing an epidemic of opioid abuse that is killing tens of thousands of people every year. Current treatment options for opioid abuse disorder include alternative...
Context: This research may provide insight into human articular cartilage development, repair mechanisms, and diseases such as arthritis. Objective: The purpose of this study is to compare the proximal femur articular cartilage...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. Surrounded by a phospholipid monolayer, they store excess cellular free fatty acids and...
CONTEXT. Prior research has shown that nursing home residents have a significant burden of symptoms including pain, nervous and depressed feelings, fatigue, and lack of energy. OPTIMISTIC is an 8-year initiative funded by the...
Hypertension is an established risk factor for the development of atrial fibrillation (AF). We evaluated the association and population impact of hypertension defined using the new 2017 guidelines on risk of AF. In this...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. They are surrounded by a phospholipid monolayer and store excess cellular free fatty...
Coxiella burnetii is an obligate intracellular bacterial pathogen and causative agent of Q fever. Chronic Q-fever manifests as potentially fatal endocarditis weeks to years after initial infection, suggesting Coxiella’s ability...
Context: Sickle Cell Disease (SCD) is characterized by an inherited point mutation in the hemoglobin (Hgb) HBB gene, which results in hemoglobin polymerization and red blood cell sickling when not fully oxygenated. Inflammatory...
Coxiella burnetii is a Gram-negative obligate intracellular pathogen, which spreads via inhalation. Although it initially infects alveolar macrophages, it can cause endocarditis several months to years after infection. This...
Osteocyte (Ot)-derived Sclerostin (Scl), encoded by the SOST gene, regulates bone homeostasis by acting on osteoblasts, inhibiting bone formation and stimulating bone resorption. Emerging evidence suggest that Scl has...