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de Caestecker, M.

Palavra-chave

Bone Morphogenetic Protein Receptors

Tipo de recurso

Article

1. Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

Correspondências de palavras-chave:
O Criador:: Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.
Descrição:: More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...
Tipo:: Article

2. BMP Signaling in Vascular Development and Disease.

Correspondências de palavras-chave:
O Criador:: Lowery, Jonathan W. and de Caestecker, M.
Descrição:: Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...
Tipo:: Article

3. Increased Susceptibility to Hypoxic Pulmonary Hypertension in Bmpr2 Mutant Mice is Associated with Endothelial Dysfunction in the Pulmonary Vasculature

Correspondências de palavras-chave:
O Criador:: Brink, M., Frank, D.B., Reese, J., Lowery Jonathan W., Anderson, L., and de Caestecker, M.
Descrição:: Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...
Tipo:: Article