Context: Patients with large staghorn calculi are commonly treated with percutaneous nephrolithotomy (PCNL). PCNL access can be technically challenging and has potential to result in significant radiation exposure to both the...
Purpose: The purpose of this study is to identify which texture analysis metrics calculated from apparent diffusion coefficient (ADC) maps from patients with head and neck squamous cell carcinomas (HNSCC) provide quantifiable...
“The legacy of slavery still shadows the American health-care system The inequalities of the health system were built in from the beginning,” said former Harvard College Dean Evelynn M. Hammonds.
The legacy of slavery as a...
The dramatic increase in the prevalence of antibiotic resistant (AR) genes
in numerous bacterial species has been a heavily discussed topic within
the scientific community. Antibiotic resistant bacteria pose a serious
threat...
Antibiotic resistance is not only a major threat to public health, with more than
700,000 deaths per year, but also has serious economic impacts.1 Nosocomial-
acquired antibiotic-resistant infections have well-established...
Hyperglycemic clamps are used as a gold standard measurement of beta cell function, allowing for measurement of a biphasic insulin response. Under this technique, the plasma glucose concentration is raised to a target...
Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteoclasts, and osteocytes. WNT signaling through low-density lipoprotein receptor related protein 5/6 (LRP5/LRP6) is one of the...
Sudden cardiac death (SCD), is a relatively rare but dangerous occurrence for athletes across the globe. Increasing attention has been drawn to the condition, especially for the likes of highly competitive athletes. Current...
There are limited data regarding the level of research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016...
There are limited data regarding the research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016 study of...
There are limited data regarding research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016 study of...
There is a lack of data regarding real and perceived barriers to research participation among osteopathic medical students (OMS’s). We have previously addressed this open question by surveying incoming first-year OMS1’s and...
Phosphorus equilibrium in the body is regulated through uptake and release via the intestine, kidney and bone. These processes are coordinated through the activity and regulation of Fibroblast Growth Factor 23 (FGF23). FGF23 is...
70% at 2 weeks post-surgery (p>0.05). Stimulus- independent pain behavior was also evident in both vehicle and BMP-2 treated CSD animals as defined by asymmetric directed behaviors including flinching, licking, lifting, and...
BACKGROUND: With an aging world population, there is an increased risk of fracture and impaired fracture healing. Enhancement of angiogenesis is one potential mechanism for improved fracture healing. The question then becomes:...
In the late 1990s, doctors were told by pharmaceutical companies that opioid pain relievers were not addictive and that they could prescribe them freely to patients in severe pain. As a result, doctors began prescribing opioid...
Context: Prior studies have identified significant health benefits and socioeconomic barriers to fruit and vegetable consumption. Objective: This study describes characteristics and physiological outcomes relative to the fruit...
Introduction: It is well documented in the literature that Bitter Melon Extract (BME) inhibits the growth and proliferation of MCF-7 breast cancer cells. While the exact mechanism of this inhibition is unknown, it is possible...
Gestational diabetes mellitus (GDM) is an increasingly prevalent complication of preg-nancy leading to adverse maternal outcomes for years postpartum. This primary litera-ture review was conducted to explore what complications...
Malignant mesothelioma typically presents in patients with asbestos exposure, with respiratory symptoms caused by primary pleural involvement with associated pleural effusion. Instead, this patient presented with a rapidly...
GnRHR signaling has been demonstrated to affect cancer cell proliferation. The expression of GnRH binding sites in leukemias and lymphomas provides a potential target for chemotherapeutic drugs. Analyzing the effect of GnRHR...
Efforts to reduce health disparities and increase access to underserved populations may be outpaced as populations diversify further. Early exposure of Diversity, Equity, Inclusion, Accessibility, and Belonging (DEIAB)...
Insulin resistance is associated with a high cumulative risk of AD and reduced cerebral glucose metabolism. New data suggest that increased hexosamine biosynthesis pathway (HBP) activity induces insulin resistance in adipose...
The history and use of virtual and augmented reality dates back to the early 19th Century, Charles Wheatstone an English scientist, and inventor discovered that the brain interrupts stereoscopic photos and paintings differently...
Context: We aimed to determine the availability of price estimates from hospitals in the United States for a pediatric orthopaedic surgical procedure (closed reduction and pinning of a distal radius fracture), and identify...
Background: Inflammatory Bowel Disease (IBD) is a chronic relapsing and remitting inflammatory disease that affects the GI tract. IBD has two major types: Crohn’s disease and Ulcerative Colitis. IBD occurs when the immune...
Multiple drug resistance is becoming increasingly problematic in the U.S., where antibiotics are overused both in agriculture and healthcare. One way bacteria can develop this resistance is through acquisition of antibiotic...
Osteoporosis, a disease of low bone mineral density, affects 10 million Americans and triggers significant health problems and considerable socioeconomic burdens. Current treatments for osteoporosis have significant...
The Bone Morphogenetic Protein (BMP) signaling pathway comprises the largest subdivision of the Transforming Growth Factor (TGFβ) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal...
Osteoporosis, a disease of low bone mineral density, affects 10 million Americans and is a significant health problem and a considerable socioeconomic burden. Current treatments for osteoporosis have significant limitations,...
Osteoporosis is a disease of low bone mass resulting from bone resorption exceeding bone formation that places individuals at enhanced risk for fracture, disability, and death. There is an urgent and unmet need for novel...
Many Gram negative bacteria including Salmonella enterica species exhibit evolving multi-drug resistance coded for on their chromosome and on mobile genetic elements. Salmonella species carrying multi-drug resistance plasmids...
In recent medical history, vaccinations have facilitated the reduction/eradication of many transmissible diseases (Olusanya et al., 2021). Recently, a growing reluctance of parents to vaccinate their children is a pertinent...
Coxiella burnetti is an obligate intracellular bacterial pathogen that spreads to humans via inhalation, infects alveolar macrophages and causes the worldwide zoonosis known as Q fever. Acutely, Coxiella infection manifests as...
Coxiella burnetii, the known causative agent of Q fever, is an obligate intracellular bacterium capable of infecting host alveolar macrophages and residing within these cells for several years. While causing mild symptoms at...
Context: Sickle Cell Disease (SCD) is characterized by an inherited point mutation in the hemoglobin (Hgb) HBB gene, which results in hemoglobin polymerization and red blood cell sickling when not fully oxygenated. Inflammatory...
Sarcopenia is a disease characterized by degeneration of muscle and strength that puts individuals at increased risk of functional impairment, physical disability, and mortality. The risk of disability is 1.5 to 4.6 times...
Cold-induced vasodilation (CIVD) is a phenomenon involving a counterintuitive increase in skin blood flow during cold exposure. Although CIVD was first described in 1930, CIVD mechanisms remain unknown. CIVD research has...
Objective Adolescent and young adult cancer survivors (AYACS: ages 15-39) have an 84.5% five -year survival rate. AYACS have a 10 times greater risk to develop cardiac disease compared to healthy peers. This is in part due to...
Candida albicans and Candida glabrata, are two clinically relevant strains of yeast. They make up a majority of commonly seen pathologies such as vaginal yeast infections, nosocomial infections, and infections of...
Hormone replacement therapy (HRT) is a common treatment for gender dysphoria, a condition where a person’s gender assigned at birth does not match their gender identify. For transgender men seeking to achieve virilization, HRT...
Context: Obesity is a prevalent disease that presents with fatal comorbidities. However, Laparoscopic Roux-en Y gastric bypass surgery patients lose all excess weight within 2 years with proven remission of comorbidities like...
Epilepsy is one of the most common brain disorders and is characterized by the recurrence of unprovoked seizures. It affects over 70 million people worldwide, 3.4 million in the U.S. alone, and it is estimated 1 in 26 people in...
The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a...
Redox systems are an important component of the cellular metabolism. We have characterized a novel thioredoxin-like protein (TrxL-1) of the malaria parasite Plasmodium and have previously determined that the trxl-1 gene is...
Cancer cells have shown to exhibit enhanced potential to metastasize via increased actin-myosin crossbridge formation, which requires increased Ca2+ influx via the voltage-gated calcium channels. This then leads to the...