Objective: A proof-of-concept for a platform designed to provide simulations modeling, in three dimensions, anatomical pathology/dysfunctions(as defined by osteopathic diagnostic criteria). Design/Methods: Data from a two...
Osteoporosis is a disease of decreased bone density that occurs when bone resorption exceeds bone formation, thereby placing individuals at greater risk of fracture and disability. We previously reported that deletion of the...
Context: Patient reminder notifications have been widely utilized in the healthcare setting for several decades. Some clinics have even begun implementing “arrival time” notifications in lieu of the term “appointment time” in...
Osteocyte (Ot)-derived Sclerostin (Scl), encoded by the SOST gene, regulates bone homeostasis by acting on osteoblasts, inhibiting bone formation and stimulating bone resorption. Emerging evidence suggest that Scl has...
Coxiella burnetii is a Gram-negative obligate intracellular pathogen, which spreads via inhalation. Although it initially infects alveolar macrophages, it can cause endocarditis several months to years after infection. This...
Context: Sickle Cell Disease (SCD) is characterized by an inherited point mutation in the hemoglobin (Hgb) HBB gene, which results in hemoglobin polymerization and red blood cell sickling when not fully oxygenated. Inflammatory...
Coxiella burnetii is an obligate intracellular bacterial pathogen and causative agent of Q fever. Chronic Q-fever manifests as potentially fatal endocarditis weeks to years after initial infection, suggesting Coxiella’s ability...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. They are surrounded by a phospholipid monolayer and store excess cellular free fatty...
Hypertension is an established risk factor for the development of atrial fibrillation (AF). We evaluated the association and population impact of hypertension defined using the new 2017 guidelines on risk of AF. In this...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. Surrounded by a phospholipid monolayer, they store excess cellular free fatty acids and...