Over the past twenty years, opioid drug use has increased, causing an epidemic of opioid abuse that is killing tens of thousands of people every year. Current treatment options for opioid abuse disorder include alternative...
Context: This research may provide insight into human articular cartilage development, repair mechanisms, and diseases such as arthritis. Objective: The purpose of this study is to compare the proximal femur articular cartilage...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. Surrounded by a phospholipid monolayer, they store excess cellular free fatty acids and...
CONTEXT. Prior research has shown that nursing home residents have a significant burden of symptoms including pain, nervous and depressed feelings, fatigue, and lack of energy. OPTIMISTIC is an 8-year initiative funded by the...
Hypertension is an established risk factor for the development of atrial fibrillation (AF). We evaluated the association and population impact of hypertension defined using the new 2017 guidelines on risk of AF. In this...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. They are surrounded by a phospholipid monolayer and store excess cellular free fatty...
Coxiella burnetii is an obligate intracellular bacterial pathogen and causative agent of Q fever. Chronic Q-fever manifests as potentially fatal endocarditis weeks to years after initial infection, suggesting Coxiella’s ability...
Context: Sickle Cell Disease (SCD) is characterized by an inherited point mutation in the hemoglobin (Hgb) HBB gene, which results in hemoglobin polymerization and red blood cell sickling when not fully oxygenated. Inflammatory...
Coxiella burnetii is a Gram-negative obligate intracellular pathogen, which spreads via inhalation. Although it initially infects alveolar macrophages, it can cause endocarditis several months to years after infection. This...
Osteocyte (Ot)-derived Sclerostin (Scl), encoded by the SOST gene, regulates bone homeostasis by acting on osteoblasts, inhibiting bone formation and stimulating bone resorption. Emerging evidence suggest that Scl has...
Context: Patient reminder notifications have been widely utilized in the healthcare setting for several decades. Some clinics have even begun implementing “arrival time” notifications in lieu of the term “appointment time” in...
Osteoporosis is a disease of decreased bone density that occurs when bone resorption exceeds bone formation, thereby placing individuals at greater risk of fracture and disability. We previously reported that deletion of the...
Objective: A proof-of-concept for a platform designed to provide simulations modeling, in three dimensions, anatomical pathology/dysfunctions(as defined by osteopathic diagnostic criteria). Design/Methods: Data from a two...
Coxiella burnetii is an obligate intracellular bacterium and causative agent of culture-negative endocarditis. Although Coxiella initially infects alveolar macrophages, it is found in lipid droplet (LD)-containing foamy...
Context: Skeletal unloading due to disuse, disease, or aging increases bone loss and the risk of skeletal fracture. Conversely, mechanical loading is anabolic to the skeleton, promoting skeletal integrity through increased bone...
Context: Indwelling Urinary Catheterization (IUC) is among the most common procedures performed in the inpatient setting. Because there are risks associated with IUC, efforts to reduce its use when unnecessary should be made....
Sudden cardiac death (SCD), is a relatively rare but dangerous occurrence for athletes across the globe. Increasing attention has been drawn to the condition, especially for the likes of highly competitive athletes. Current...
Context: Children with SMA suffer from scoliosis, global weakness, and Thoracic Insufficiency (TIS). Normalized pulmonary function tests are inadequate when evaluating these patients for improvement in PFTs. Objective: Forced...
Context: We aimed to determine the availability of price estimates from hospitals in the United States for a pediatric orthopaedic surgical procedure (closed reduction and pinning of a distal radius fracture), and identify...
Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone formation...
Multiple drug resistance is becoming increasingly problematic in the U.S., where antibiotics are overused both in agriculture and healthcare. One way bacteria can develop this resistance is through acquisition of antibiotic...
Context: Skeletal muscle is essential for proper bodily functions by playing key roles in strength and movement, and it accounts for roughly 50% of our total body mass. Decreases in total muscle mass or mass-specific function...
Context: The purpose of this project was to design a 3-dimensional method for visualizing structures within the brainstem with special attention to those involved in Lateral Medullary (Wallenberg) Syndrome. Wallenberg syndrome...
Redox systems are an important component of the cellular metabolism. We have characterized a novel thioredoxin-like protein (TrxL-1) of the malaria parasite Plasmodium and have previously determined that the trxl-1 gene is...
Context: Obesity is a prevalent disease that presents with fatal comorbidities. However, Laparoscopic Roux-en Y gastric bypass surgery patients lose all excess weight within 2 years with proven remission of comorbidities like...
There are limited data regarding research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016 study of...
Purpose: To establish an ex vivo model of paclitaxel induced peripheral neuropathy that can be translated clinically using induced human neurons. Experimental Design: Human induced pluripotent stem cells (iPSCs) will be...
The great saphenous vein (GSV) should be considered as a vascular access point in cases of difficult access such as in trauma patients or hypovolemic patients. The GSV has been proven to be a viable vessel for peripheral venous...
Osteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer...
Odds ratios are one of the methods in statistics to quantify how strongly the presence or absence of a property correlates with the presence or absence of another property in a given population. In the biomedical sciences they...
Neurosurgical procedures result in surgically-induced brain injury (SBI) that causes postoperative complications including brain edema and neuronal apoptosis in the surrounding brain tissue. SBI leads to the release of...
Context: Prior studies have identified significant health benefits and socioeconomic barriers to fruit and vegetable consumption. Objective: This study describes characteristics and physiological outcomes relative to the fruit...