Title

Effects of Whole-Body Heating on Skin Blood Flowmotion in Rosacea

Document Type

Poster

Publication Date

2015

Disciplines

Medicine and Health Sciences

Abstract

Previous research indicates that sympathetic outflow to the face may be altered in rosacea (Metzler-Wilson & Toma, et al, J Neurophysiol, 2015). To identify if control and regulatory mechanisms of skin blood flow (SkBF) are affected by these outflow differences, SkBF oscillations were assessed in subjects with and without rosacea during basal conditions and during symptom-triggering heat stress. We hypothesized that individuals with rosacea would demonstrate greater changes in spectral power in the low (LF; 0.02-0.06 Hz; sympathetic) but not the very-low (VLF; 0.009-0.02 Hz; vascular endothelial) frequency range in a facial skin site during systemic heating. Nine otherwise healthy subjects with rosacea and healthy age-sex matched controls underwent whole-body heating to increase SkBF and trigger symptoms. Forehead SkBF (laser-Doppler flowmetry) was measured during whole-body heating via perfusing 50 °C water through a tube-lined suit for ~30-60 min. Changes in SkBF spectral power in VLF and LF ranges from baseline to heating were determined using fast-Fourrier transform. Both groups increased spectral power within both the VLF and LF ranges. Compared to healthy controls, individuals with rosacea trended toward greater changes in LF SkBF spectral power (1.48 ± 0.68 vs. 0.31 ± 0.34 au, for rosacea and control, respectively; p=0.08). There were no significant differences in the change in VLF SkBF spectral power between groups (p=0.14). These data indicate that individuals with rosacea may have alterations in sympathetic but not vascular endothelial mechanisms of control of facial SkBF during symptom-triggering systemic heat stress.

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