Title

BMP Signaling in Vascular Development and Disease.

Document Type

Article

Publication Date

8-1-2010

Published In / Presented At

Cytokine & Growth Factor Reviews

Disciplines

Cells | Cellular and Molecular Physiology | Embryonic Structures | Medicine and Health Sciences | Physiology

Abstract

Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis and disease in the adult. However, discrepancies between in vitro and in vivo findings and distinct functional properties of the BMP signaling pathway in different vascular beds, have led to controversies in the field that have been difficult to reconcile. This review attempts to clarify some of these issues by providing an up to date overview of the biology and genetics of BMP signaling relevant to the intact vasculature.

Rights

Creative Commons Attribution Non-Commercial No Derivatives License (CC BY-NC-ND 4.0)

DOI

10.1016/j.cytogfr.2010.06.001